Patient-specific 3D hemodynamics modelling of left coronary artery under hyperemic conditions
| Autor: | Irfan Anjum Badruddin, Ahmad Badarudin, Kalimuthu Govindaraju, Girish N. Viswanathan, N. Nik-Ghazali, T. M. Yunus Khan, N.J. Salman Ahmed, Sarfaraz Kamangar |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Patient-Specific Modeling medicine.medical_specialty 0206 medical engineering Biomedical Engineering Hemodynamics Blood Pressure Hyperemia 02 engineering and technology Fractional flow reserve 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Left coronary artery Imaging Three-Dimensional medicine.artery Internal medicine Coronary Circulation medicine Shear stress Humans Computer Simulation Pressure drop Cardiac cycle business.industry Coronary Stenosis Models Cardiovascular Middle Aged medicine.disease 020601 biomedical engineering Coronary Vessels Computer Science Applications Fractional Flow Reserve Myocardial Stenosis medicine.anatomical_structure Cardiology Stress Mechanical business Shear Strength Blood Flow Velocity Artery |
| Zdroj: | Medicalbiological engineeringcomputing. 55(8) |
| ISSN: | 1741-0444 |
| Popis: | The purpose of this study is to investigate the effect of various degrees of percentage stenosis on hemodynamic parameters during the hyperemic flow condition. 3D patient-specific coronary artery models were generated based on the CT scan data using MIMICS-18. Numerical simulation was performed for normal and stenosed coronary artery models of 70, 80 and 90% AS (area stenosis). Pressure, velocity, wall shear stress and fractional flow reserve (FFR) were measured and compared with the normal coronary artery model during the cardiac cycle. The results show that, as the percentage AS increase, the pressure drop increases as compared with the normal coronary artery model. Considerable elevation of velocity was observed as the percentage AS increases. The results also demonstrate a recirculation zone immediate after the stenosis which could lead to further progression of stenosis in the flow-disturbed area. Highest wall shear stress was observed for 90% AS as compared to other models that could result in the rupture of coronary artery. The FFR of 90% AS is found to be considerably low. |
| Databáze: | OpenAIRE |
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