Association between polymorphisms of the renin–angiotensin system and coronary artery disease in Chinese patients with type 2 diabetes
| Autor: | Jie-Ning Zhu, Zhi-Xin Shan, Qiu-Xiong Lin, Shu-Guang Lin, He-Ping Lei, Qing-Zhou Yao, Min Yang, Shi-Long Zhong, Hong-hong Tan, Xi-Yong Yu, Hong-mei Chen, Zhi-Ling Zhou, Zhi-Wei Zheng |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Male
China medicine.medical_specialty Medicine (General) Multifactor Dimensionality Reduction Genotyping Techniques Coronary Artery Disease Type 2 diabetes Polymorphism Single Nucleotide Gastroenterology Renin-Angiotensin System Coronary artery disease Endocrinology R5-920 Asian People Gene Frequency Diabetes mellitus Internal medicine Genotype Internal Medicine medicine Humans Allele Genetic Association Studies Aged Models Genetic Multifactor dimensionality reduction business.industry Type 2 Diabetes Mellitus Epistasis Genetic Middle Aged medicine.disease Logistic Models Diabetes Mellitus Type 2 Female Gene polymorphism business |
| Zdroj: | Journal of the Renin-Angiotensin-Aldosterone System, Vol 13 (2012) |
| ISSN: | 1752-8976 1470-3203 |
| Popis: | Background : The renin–angiotensin system (RAS) is regarded as one of the most important regulatory systems for cardiovascular homeostasis. In this study, we investigated associations of the five genetic polymorphisms in the RAS and presence of coronary artery disease (CAD) in type 2 diabetes. Methods : Genotyping was performed by polymerase chain reaction–restriction fragment length polymorphism analysis. We used the generalised multifactor dimensionality reduction (GMDR) method to identify gene–gene interactions. Results : The D allele in the ACE gene was significantly more frequent in type 2 diabetic patients with CAD ( p = 0.04). In multivariate logistic regression analysis, the DD genotype was associated with a significantly increased risk of CAD ( p = 0.044). 1675G/A variant in the AT2R gene was found to be associated with CAD in female subjects with type 2 diabetes ( p = 0.025). The three other polymorphisms of the RAS do not seem to influence the development of CAD in type 2 diabetes. No significant gene–gene interaction for any combinations of genotypes was found in the GMDR method. Conclusion : The DD variant of the ACE gene polymorphism is associated with increased risk of developing CAD in Chinese patients with type 2 diabetes. A slight impact of AT2R 1675G/A polymorphism on CAD was found only in female diabetic patients. |
| Databáze: | OpenAIRE |
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