Immunopathogenesis and Therapeutic Approaches in Pediatric Celiac Disease
| Autor: | Terence L. Zach, Devendra K. Agrawal, Shreya Agarwal, Oormila Kovilam |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult medicine.medical_specialty Glutens Immunology Autoimmunity Disease Autoimmune enteropathy medicine.disease_cause Article Pathogenesis 03 medical and health sciences 0302 clinical medicine medicine Immunology and Allergy Humans Genetic Predisposition to Disease Intestinal Mucosa Intensive care medicine Child Sensitization chemistry.chemical_classification Modalities business.industry Incidence (epidemiology) Infant Newborn Infant medicine.disease Gluten Celiac Disease 030104 developmental biology medicine.anatomical_structure chemistry 030211 gastroenterology & hepatology Chorionic Villi business Algorithms Diet Therapy |
| Popis: | Celiac Disease is an autoimmune enteropathy with increasing incidence worldwide in both adults and children. It occurs as an inflammatory condition with destruction of the normal architecture of villi on consumption of gluten and related protein products found in wheat, barley and rye. However, the exact pathogenesis is not yet fully understood. A gluten-free diet remains the main modality of therapy to date. While some patients continue to have symptoms even on a gluten-free diet, adherence to this diet is also difficult, especially for the children. Hence, there is continued interest in novel methods of therapy and the current research focus is on the promising novel non-dietary modalities of treatment. Here, we critically reviewed the existing literature regarding the pathogenesis of celiac disease in children including the role of in-utero exposure leading to neonatal and infant sensitization and its application for the development of new therapeutic approaches for these patients. |
| Databáze: | OpenAIRE |
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