Role of miRNA-182 and miRNA-187 as potential biomarkers in prostate cancer and its correlation with the staging of prostate cancer
| Autor: | Brusabhanu Nayak, Yashika Rustagi, Prabhjot Singh, Amit K. Dinda, Harshit Garg, Seema Kaushal, Naveed Khan, Amlesh Seth |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Oncology medicine.medical_specialty Urology 030232 urology & nephrology Urine lcsh:RC870-923 Correlation 03 medical and health sciences Prostate cancer 0302 clinical medicine Antigen Internal medicine microRNA Biopsy Biomarkers Tumor medicine Humans Prospective Studies Aged medicine.diagnostic_test business.industry Prostatic Neoplasms Bone metastasis Middle Aged lcsh:Diseases of the genitourinary system. Urology medicine.disease MicroRNAs 030220 oncology & carcinogenesis Original Article Histopathology business Biomarkers |
| Zdroj: | International braz j urol, Volume: 46, Issue: 4, Pages: 614-623, Published: 01 JUN 2020 International Brazilian Journal of Urology : official journal of the Brazilian Society of Urology International braz j urol v.46 n.4 2020 International Braz J Urol Sociedade Brasileira de Urologia (SBU) instacron:SBU International Brazilian Journal of Urology, Vol 46, Iss 4, Pp 614-623 |
| ISSN: | 1677-6119 1677-5538 |
| DOI: | 10.1590/s1677-5538.ibju.2019.0409 |
| Popis: | Purpose The microRNAs expression has emerged as a potential biomarker for the diagnosis and prognosis of prostate cancer. This study investigated the expression of miRNA-182 and miRNA-187 in prostate cancer patients and established a correlation between miRNA expression and staging of prostate cancer. Materials and Methods This prospective observational study involved patients undergoing transrectal ultrasound-guided biopsy for suspicion of prostate cancer. Pre-biopsy urine samples and prostatic core tissue samples of the patients were preserved and the miRNA-182 and miRNA-187 were studied. Results Sixty-three patients were included in this study, thirty-three patients were diagnosed with prostate cancer and thirty patients having benign histopathology were considered as controls. The expression of miRNA-182 was significantly increased (p=0.002) and miRNA-187 significantly decreased (p |
| Databáze: | OpenAIRE |
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