Clinical and immunogenetic characteristics of European multicase rheumatoid arthritis families
| Autor: | Paola Migliorini, Dora Pascual-Salcedo, Rene Westhovens, G. De Almeida, P Fritz, A. Lopes-Vaz, Thomas Bardin, C. Stravopoulos, Dominique Charron, K Maenaut, Helena Alves, M Spaepen, François Cornelis, Lucrezia Riente, Virginia Lepage, Jean-François Prud'homme, Trdj Radstake, Pilar Barrera, Alejandro Balsa, Maria Martinez |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male medicine.medical_specialty Concordance Immunology Arthritis Disease General Biochemistry Genetics and Molecular Biology Arthritis Rheumatoid Rheumatology Rheumatoid Factor Epidemiology Humans Immunology and Allergy Medicine Rheumatoid factor Age of Onset Sex Distribution Alleles Aged business.industry HLA-DR Antigens Middle Aged medicine.disease Connective tissue disease Europe Extended Report Rheumatoid arthritis Female Age of onset business HLA-DRB1 Chains Demography |
| Zdroj: | Annals of the Rheumatic Diseases. 60:573-576 |
| ISSN: | 0003-4967 |
| Popis: | OBJECTIVE—To describe the characteristics of a new set of European families with affected sib pairs (ASP) collected by the European Consortium on Rheumatoid Arthritis Families (ECRAF) to replicate the results of our first genome scan. Potential gradients for disease severity in Europe and concordance within families were studied. PATIENTS AND METHODS—From 1996 to 1998 European white families with at least two affected siblings were enrolled in the study. Demographic (sex, age at onset), clinical data (rheumatoid factor (RF), disease duration, erosive disease, extra-articular features (EF)), and HLA-DRB1 oligotyping were analysed. RESULTS—565 patients with rheumatoid arthritis (RA), belonging to 271 families including 319 affected sib pairs (ASP) were collected. Belgium, France, Italy, the Netherlands, Portugal, and Spain contributed 20, 96, 52, 24, 9, and 70 families, respectively. Sex (78% women), age at onset (mean 44 years), and RF positivity (79%) were similar among the countries. Differences were found in disease duration (11-18 years) and in the prevalence of erosive disease (70-93%), nodules (15-44%), subjective Sjögren's syndrome (5-38%), and EF (3-16%) (p |
| Databáze: | OpenAIRE |
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