Effects of vitamin E on neurodegenerative diseases: an update
| Autor: | Mehmet Arif Icer, Makbule Gezmen-Karadag, Neslihan Arslan |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_treatment Vitamin e supplementation Disease medicine.disease_cause Bioinformatics 03 medical and health sciences 0302 clinical medicine Alzheimer Disease medicine Animals Humans Vitamin E Amyotrophic lateral sclerosis Stroke business.industry General Neuroscience Amyotrophic Lateral Sclerosis Neurodegeneration Neurodegenerative Diseases Parkinson Disease General Medicine medicine.disease 030104 developmental biology Vitamin E deficiency business Behavioral Sciences 030217 neurology & neurosurgery Oxidative stress |
| Zdroj: | Acta Neurobiologiae Experimentalis. 81(1):21 |
| ISSN: | 1689-0035 0065-1400 |
| DOI: | 10.21307/ane-2021-003 |
| Popis: | Vitamin E deficiency is associated with many neurological problems. Although the mechanisms of vitamin E action in neurodegenerative diseases are not clear, there are many possible mechanisms. Examples of such mechanisms are the protective effects of vitamin E against oxidative stress damage and its suppressive role in the expression of many genes involved in the development of neurodegeneration. Many studies have evaluated the relationship between vitamin E intake or vitamin E levels in body fluids and neurodegenerative diseases. Some studies concluded that vitamin E can play a protective role in neurodegeneration with respect to diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), stroke and amyotrophic lateral sclerosis (ALS). Vitamin E supplementation was also associated with risk factors for some neurodegenerative diseases. In this review, we discuss the possible effects of vitamin E on the development and course of AD, PD, stroke and ALS, and the potential mechanisms involved. Vitamin E deficiency is associated with many neurological problems. Although the mechanisms of vitamin E action in neurodegenerative diseases are not clear, there are many possible mechanisms. Examples of such mechanisms are the protective effects of vitamin E against oxidative stress damage and its suppressive role in the expression of many genes involved in the development of neurodegeneration. Many studies have evaluated the relationship between vitamin E intake or vitamin E levels in body fluids and neurodegenerative diseases. Some studies concluded that vitamin E can play a protective role in neurodegeneration with respect to diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), stroke and amyotrophic lateral sclerosis (ALS). Vitamin E supplementation was also associated with risk factors for some neurodegenerative diseases. In this review, we discuss the possible effects of vitamin E on the development and course of AD, PD, stroke and ALS, and the potential mechanisms involved. |
| Databáze: | OpenAIRE |
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