Site-Selective Aerobic C-H Monoacylation of Carbazoles Using Palladium Catalysis
| Autor: | Tirtha Mandal, Subhadip Maiti, Jyotirmayee Dash, Barada Prasanna Dash |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
010405 organic chemistry Organic Chemistry chemistry.chemical_element 010402 general chemistry 01 natural sciences Aldehyde Oxygen Toluene Combinatorial chemistry Article 0104 chemical sciences Catalysis Acylation chemistry.chemical_compound Dual role chemistry Site selective lipids (amino acids peptides and proteins) Palladium |
| Zdroj: | J Org Chem |
| ISSN: | 1520-6904 |
| Popis: | This manuscript describes the development of a remarkably general palladium catalyzed mono-acylation of carbazoles using toluene derivatives playing the dual role of acyl source and organic solvent. The method uses NHPI as the co-catalyst and oxygen as the sole oxidant. Interestingly, the acylation of monosubstituted N-pyridyl carbazoles takes place regioselectively at the C-8 position. The scope of the method is explored using aldehyde as the acyl source. This highly site-selective acylation proceeds through a radical process. [Figure: see text] |
| Databáze: | OpenAIRE |
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