Systemic delivery of blood–brain barrier-targeted polymeric nanoparticles enhances delivery to brain tissue
| Autor: | W. Mark Saltzman, Jennifer K. Saucier-Sawyer, Junwei Zhang, Young-Eun Seo, Yang Deng, Elias Quijano, Christopher J. Cheng |
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| Rok vydání: | 2015 |
| Předmět: |
Polymers
Central nervous system Pharmaceutical Science Pharmacology Blood–brain barrier Article Mice Drug Delivery Systems Cell Line Tumor Glioma Polymer chemistry medicine Animals Humans Tissue Distribution Drug Carriers Mice Inbred BALB C Brain Neoplasms Chemistry Brain Biological Transport Neoplasms Experimental medicine.disease Antineoplastic Agents Phytogenic Controlled release Adenosine medicine.anatomical_structure Blood-Brain Barrier Delayed-Action Preparations Nanoparticles for drug delivery to the brain Injections Intravenous Nanoparticles Camptothecin Drug carrier medicine.drug |
| Zdroj: | Journal of Drug Targeting. 23:736-749 |
| ISSN: | 1029-2330 1061-186X |
| DOI: | 10.3109/1061186x.2015.1065833 |
| Popis: | Delivery of therapeutic agents to the central nervous system is a significant challenge, hindering progress in the treatment of diseases such as glioblastoma. Due to the presence of the blood-brain barrier (BBB), therapeutic agents do not readily transverse the brain endothelium to enter the parenchyma. Previous reports suggest that surface modification of polymer nanoparticles can improve their ability to cross the BBB, but it is unclear whether the observed enhancements in transport are large enough to enhance therapy. In this study, we synthesized two degradable polymer nanoparticle systems surface-modified with ligands previously suggested to improve BBB transport, and tested their ability to cross the BBB after intravenous injection in mice. All nanoparticle preparations were able to cross the BBB, although generally in low amounts ( |
| Databáze: | OpenAIRE |
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