Imaging of human aortic atherosclerotic plaques by polarization-sensitive optical coherence tomography
| Autor: | Gwo-Jen Jan, Jeou-Jong Shyu, Nai-Kuan Chou, Chih Ming Lai, Wen Chuan Kuo, Hsiang-Yun Huang, Chien Chou |
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| Rok vydání: | 2005 |
| Předmět: |
Materials science
Birefringence genetic structures medicine.diagnostic_test business.industry Optical polarization Polarization (waves) eye diseases Image contrast Polarization sensitive Optics Optical coherence tomography medicine Ultrasound imaging sense organs Optical tomography business Biomedical engineering |
| Zdroj: | The 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. |
| DOI: | 10.1109/iembs.2004.1403389 |
| Popis: | Optical coherence tomography (OCT) is analogous to ultrasound imaging except that it uses infrared light instead of sound. Polarization-sensitive optical coherence tomography (PS-OCT) combines the advantages of OCT and provides additional image contrast of the tested sample. We demonstrate this technique for imaging of back-reflected light, birefringence, and fast-axis orientation simultaneously in different kinds of atherosclerosis plaque. This in vitro study suggests birefringence changes in plaque are due to the prominent deposition of collagen or cholesterol by correlating PS-OCT images with histology. Thus the combination of high resolution structural imaging and birefringence detection make PS-OCT a potentially powerful tool for early assessment of atherosclerosis appearance and prediction of plaque rupture. |
| Databáze: | OpenAIRE |
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