Capsaicin-evoked release of immunoreactive calcitonin gene-related peptide from the spinal cord is mediated by nitric oxide but not by cyclic GMP
| Autor: | Lloyd P. Walton, Mary G. Garry, Michael Davis |
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| Rok vydání: | 2000 |
| Předmět: |
Male
medicine.medical_specialty Calcitonin Gene-Related Peptide Neuropeptide Kainate receptor Nitric Oxide Synthase Type I AMPA receptor Calcitonin gene-related peptide Nitric Oxide Nitric oxide Rats Sprague-Dawley chemistry.chemical_compound Internal medicine medicine Animals Enzyme Inhibitors Cyclic GMP Molecular Biology General Neuroscience Rats Posterior Horn Cells Endocrinology Spinal Cord chemistry Capsaicin CNQX NMDA receptor Neurology (clinical) Nitric Oxide Synthase Excitatory Amino Acid Antagonists Developmental Biology |
| Zdroj: | Brain Research. 861:208-219 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/s0006-8993(99)02448-8 |
| Popis: | Recent data support a role for nitric oxide (NO) in pain processing at the level of the spinal cord, possibly via regulation of neuropeptide release. The goal of this study was to determine whether capsaicin, which selectively activates primary afferent neurons and evokes neuropeptide release, acts in an NO-dependent manner. Our results indicate that capsaicin (1 microM)-evoked release of immunoreactive calcitonin gene-related peptide (iCGRP) is significantly reduced in the presence of the NO synthase inhibitor, L-NAME (10-400 nM; F(3,45)=68.38; P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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