Chronic Stress Promotes an Immunologic Inflammatory State and Head and Neck Cancer Growth in a Humanized Murine Model

Autor: Joseph Zenga, Musaddiq J. Awan, Anne Frei, Ellie Petrie, Guru Prasad Sharma, Aditya Shreenivas, Monica Shukla, Heather A. Himburg
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Head Neck
Popis: BACKGROUND: Despite the importance of immune response and environmental stress on head and neck cancer (HNC) outcomes, no current pre-clinical stress model includes a humanized immune system. METHODS: We investigated the effects of chronic stress induced by social isolation on tumor growth and human immune response in subcutaneous HNC tumors grown in NSG-SGM3 mice engrafted with a human immune system. RESULTS: Tumor growth (p
Databáze: OpenAIRE