Gastrointestinal recovery after surgery: protocol for a systematic review
| Autor: | Wendy Babidge, Jonathan Henry W Jacobsen, Christopher K. Rayner, Peter J. Hewett, Kaitryn Campbell, Michael Horowitz, Guy J. Maddern, Gayatri P Asokan, Markus Trochsler, David R. Tivey, Brandon Stretton, Christopher D. Ovenden, John M. Glynatsis, Joshua G. Kovoor, Suzanne Edwards, Adrian Anthony, Karen L. Jones, Aashray K. Gupta, Joseph N Hewitt |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Funnel plot MEDLINE CINAHL Cochrane Library orthopaedic & trauma surgery Meta-Analysis as Topic Forest plot medicine Humans adult surgery Protocol (science) business.industry General Medicine Publication bias hepatobiliary surgery Colorectal surgery anaesthetics Surgery Research Design Medicine colorectal surgery business Publication Bias Systematic Reviews as Topic |
| Zdroj: | BMJ Open BMJ Open, Vol 11, Iss 10 (2021) |
| ISSN: | 2044-6055 |
| Popis: | IntroductionGastrointestinal recovery after surgery is of worldwide significance. Postoperative gastrointestinal dysfunction is multifaceted and known to represent a major source of postoperative morbidity, however, its significance to postoperative care across all surgical procedures is unknown. The complexity of postoperative gastrointestinal recovery is poorly defined within gastrointestinal surgery, and even less so outside this field. To inform the clinical care of surgical patients worldwide, this systematic review and meta-analysis will aim to characterise the duration of postoperative gastrointestinal recovery that can be expected across all surgical procedures and determine the associations between factors that may affect this.Methods and analysisMEDLINE, Embase, Cochrane Library and CINAHL will be searched for studies reporting the time to first postoperative passage of stool after any surgical procedure. We will screen records, extract data and assess risk of bias in duplicate. Forest plots will be constructed for time to postoperative gastrointestinal recovery, as assessed by various outcome measures. Because of potential heterogeneity, a random-effects model will be used throughout the meta-analysis. Funnel plots will be used to test for publication bias. Meta-regressions will be undertaken where the outcome is the mean time to first postoperative passage of stool, with potential predictors and confounders being patient characteristics, postoperative outcomes and surgical factors.Ethics and disseminationThis study will not involve human or animal subjects and, thus, does not require ethics approval. The outcomes will be disseminated via publication in peer-reviewed scientific journal(s) and presentations at scientific conferences.PROSPERO registration numberCRD42021256210. |
| Databáze: | OpenAIRE |
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