Enhanced conditioning of adverse memories in the mouse modified swim test is associated with neuroinflammatory changes - Effects that are susceptible to antidepressants
| Autor: | Allan A. Kalueff, Andrey Proshin, Aleksei Umriukhin, Tatyana Strekalova, D. A. Pavlov, Alexander Lysko, Anna Gorlova, Rainer Landgraf, Lucien Bettendorff, Daniel C. Anthony |
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| Přispěvatelé: | RS: MHeNs - R3 - Neuroscience, Psychiatrie & Neuropsychologie |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Imipramine pathways TNF Hippocampus posttraumatic-stress-disorder INFLAMMATORY MARKERS Antidepressive Agents Tricyclic Behavioral Neuroscience 0302 clinical medicine GSK-3 enhanced learning of adverse memories oxidative stress Major depression Prefrontal cortex 05 social sciences DEPRESSION Major depressive disorder Antidepressant Encephalitis Inflammation Mediators medicine.drug medicine.medical_specialty mice Cognitive Neuroscience brain PATHOPHYSIOLOGY Experimental and Cognitive Psychology Context (language use) 050105 experimental psychology 03 medical and health sciences Memory Internal medicine glutamate release medicine Animals Learning 0501 psychology and cognitive sciences Glycogen synthase kinase-3 (GSK-3) Neuroinflammation model glycogen-synthase kinase-3 medicine.disease cytokines Mice Inbred C57BL Disease Models Animal Endocrinology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neurobiology of Learning and Memory, 172:107227. Elsevier Science |
| ISSN: | 1074-7427 |
| Popis: | Deficient learning and memory are well-established pathophysiologic features of depression, however, mechanisms of the enhanced learning of aversive experiences associated with this disorder are poorly understood. Currently, neurobiological mechanisms of enhanced retention of aversive memories during depression, and, in particular, their relation to neuroinflammation are unclear. As the association between major depressive disorder and inflammation has been recognized for some time, we aimed to address whether neuroinflammatory changes are involved in enhanced learning of adversity in a depressive state. To study this question, we used a recently described mouse model of enhanced contextual conditioning of aversive memories, the modified forced swim model (modFST). In this model, the classic two-day forced swim is followed by an additional delayed session on Day 5, where increased floating behaviour and upregulated glycogen synthase kinase-3 (GSK-3) are context-dependent. Here, increased time spent floating on Day 5, a parameter of enhanced learning of the adverse context, was accompanied by hypercorticosteronemia, increased gene expression of GSK-3 alpha, GSK-3 beta, c-Fos, cyclooxygenase-1 (COX-1) and pro-inflammatory cytokines interleukin-1 beta (IL-1 beta), tumor necrosis factor (TNF), and elevated concentrations of protein carbonyl, a marker of oxidative stress, in the prefrontal cortex and hippocampus. There were significant correlations between cytokine levels and GSK-3 beta gene expression. Two-week administration of compounds with antidepressant properties, imipramine (7 mg/kg/day) or thiamine (vitamin B1; 200 mg/kg/day) ameliorated most of the modFST-induced changes. Thus, enhanced learning of adverse memories is associated with pro-inflammatory changes that should be considered for optimizing pharmacotherapy of depression associated with enhanced learning of aversive memories. |
| Databáze: | OpenAIRE |
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