Radix astragali and orthostatic response: a double-masked crossover study
| Autor: | Andreas Rössler, Günther Schwaberger, Erich Stöger, Nandu Goswami, Erik Konrad Grasser, Yunfang Gao, Helmut Hinghofer-Szalkay |
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| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Blood Pressure Syncope Orthostatic vital signs Tilt table test Hypotension Orthostatic Double-Blind Method Heart Rate Tilt-Table Test Internal medicine Heart rate Medicine Humans Weightlessness Simulation Presyncope Cross-Over Studies medicine.diagnostic_test business.industry Weightlessness Public Health Environmental and Occupational Health Stroke volume Astragalus propinquus medicine.disease Crossover study Surgery Pulse pressure Muscular Atrophy Blood pressure Neuromuscular Agents Cardiology business Weightlessness Countermeasures Drugs Chinese Herbal |
| Zdroj: | Aviation, space, and environmental medicine. 79(2) |
| ISSN: | 0095-6562 |
| Popis: | Aim Recent results from animal experiments have shown that radix astragali (RA), a traditional Chinese herbal tonic, alleviates muscle atrophy under simulated weightlessness conditions, rendering RA a candidate for human use as a countermeasure against muscular atrophy. Possible cardiovascular side effects have not yet been investigated. We analyzed the effects of RA on the orthostatic stability of healthy men. Methods There were 10 test subjects who were assigned to a double-blinded, randomized crossover design using RA or placebo (PL) for 14 d each, respectively. Test runs were separated by a 14-d 'washout' interval. At the beginning and the end of every 14-d test run, graded orthostatic stress (GOS) consisting of head-up tilt (HUT) combined with lower body negative pressure (LBNP) was used to achieve a presyncopal endpoint. Orthostatic effects on cardiac and vascular function were continuously monitored. Results There were no significant differences between the RA vs. PL groups: mean arterial blood pressure dropped by 13 vs. 17%, pulse pressure 46 vs. 35%, heart rate increased 108 vs. 117%, and stroke volume index decreased 54 vs. 49% from supine control to presyncope. Neither did RA influence standing time compared to PL (18 +/- 7 vs. 17 +/- 6 min), nor did progression from the first to the fourth trial (15 +/- 6 to 18 +/- 7 min). Conclusion RA does not influence resting cardiovascular variables and orthostatic capacity in humans. It can be expected that human studies of RA's musculo-skeletal countermeasure potential will not be compromised by any cardiovascular side effects at the dosage employed in this study. |
| Databáze: | OpenAIRE |
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