Changes in airway inflammation following nasal allergic challenge in patients with seasonal rhinitis
| Autor: | Michel Aubier, Marcel Bonay, Véronique Leçon-Malas, Martine Grandsaigne, Philippe Ravaud, Monique Dehoux, Catherine Neukirch |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Allergy Nasal Provocation Tests medicine.medical_treatment Immunology Severity of Illness Index Statistics Nonparametric Nasal provocation test Leukocyte Count Double-Blind Method Reference Values Forced Expiratory Volume Eosinophil activation otorhinolaryngologic diseases medicine Humans Immunology and Allergy Probability Skin Tests Asthma Inflammation Cross-Over Studies business.industry Rhinitis Allergic Seasonal Allergens respiratory system Eosinophil Nasal Lavage Fluid medicine.disease respiratory tract diseases Eosinophils medicine.anatomical_structure Cytokines Pollen Sputum Nasal Lavage Female Methacholine Bronchial Hyperreactivity medicine.symptom business medicine.drug |
| Zdroj: | Allergy. 61:111-118 |
| ISSN: | 1398-9995 0105-4538 |
| DOI: | 10.1111/j.1398-9995.2006.00967.x |
| Popis: | Background: Seasonal allergic rhinitis could predispose to the development of chronic bronchial inflammation as observed in asthma. However, direct links between nasal inflammation, bronchial inflammation and airway responsiveness in patients with seasonal allergic rhinitis and without asthma are not fully understood. The aim of this study was to analyse the changes induced by allergic nasal challenge outside the pollen season in airway responsiveness and bronchial inflammation of patients with seasonal allergic rhinitis. Methods: Nine patients were evaluated after either grass pollens or placebo nasal challenge in a randomized cross-over double-blinded trial. Nasal parameters were recorded hourly and airway responsiveness was assessed by methacholine challenge. Cytological examinations and cytokine measurements were performed in nasal lavage and induced sputum. Eosinophil activation was investigated by eosinophil-cationic protein expression and secretion. Results: Airway responsiveness was increased after allergic nasal challenge. Total eosinophils and eosinophils expressing eosinophil-cationic protein were increased in induced sputum after allergic nasal challenge. Both eosinophil number and eosinophil-cationic protein concentration in induced sputum were correlated to methacholine responsiveness. Conclusions: These results suggest that eosinophils participate to the bronchial inflammation in patients with seasonal allergic rhinitis following allergic nasal challenge outside the pollen season and might explain changes in airway responsiveness. |
| Databáze: | OpenAIRE |
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