Who are at risk for thromboembolism after arthroplasty? A systematic review and meta-analysis
| Autor: | Wei-Ping Chen, Jin Li, Wenkang Qian, Xin-die Zhou, Zhi-Gao Yang, Pengli Zhang, Lidong Wu |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Polymorphism Genetic Joint replacement business.industry medicine.medical_treatment Factor V Hematology Odds ratio Gene mutation medicine.disease Arthroplasty Surgery Pulmonary embolism Venous thrombosis Risk Factors Thromboembolism Internal medicine Meta-analysis medicine Humans Prothrombin G20210A Prothrombin Arthroplasty Replacement business Methylenetetrahydrofolate Reductase (NADPH2) |
| Zdroj: | Thrombosis Research. 132:531-536 |
| ISSN: | 0049-3848 |
| Popis: | Background Thromboembolism, including deep venous thrombosis and pulmonary embolism, is a grave threat to patients undergoing total joint replacement. Using a systematic review and meta-analysis we asked whether gene mutations or polymorphisms could be risk factors for thrombosis after arthroplasty. Methods We performed a comprehensive search of Medline, PubMed, Embase, Cochrane databases, China National Knowledge Infrastructure (CNKI), and Google Scholar, and identified 19 studies detailing genetic investigations of patients with thromboembolism following joint replacement. Results Our meta-analyses included 5149 patients who underwent arthroplasty surgery. Significant associations with venous thromboembolism were identified for factor G1691A (odds ratio (OR) 1.41, 95% confidence interval (CI) 1.03 - 1.94, p = 0.03), prothrombin G20210A (OR 2.16, 95% CI, 1.27- 3.69, p = 0.005), and MTHFR/C677T/TT (OR 2.36, 95% CI 1.03 - 5.42, p = 0.04) in Caucasian populations. No significant gene mutation was identified in Asian populations. Conclusion This study suggests a way to identify patients scheduled for arthroplasty who are at higher risk of thrombosis, enabling individualized treatment. |
| Databáze: | OpenAIRE |
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