As Evidence-Based Tumorigenic Role of Epstein-Barr Virus miR-BART1-3p in Neurological Tumors
| Autor: | Farah Bokharaei-Salim, Hossin Keyvani, Mohammad Hadi Karbalaie Niya, Farzin Sadeghii, Mohammad Karimzadeh, Saeedeh Abbasi, Maryam Esghaei, Mohsen Moghoofei, Alireza Tabibzadeh, Javid Sadri Nahand, Moein Esghaei |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Epstein-Barr Virus Infections Herpesvirus 4 Human Adolescent Neurological tumors Central nervous system miR-BART medicine.disease_cause Virus Young Adult chemistry.chemical_compound hemic and lymphatic diseases microRNA medicine Humans CNS TUMORS Aged Aged 80 and over Brain Neoplasms business.industry Cancer General Medicine Middle Aged Prognosis medicine.disease Epstein–Barr virus MicroRNAs medicine.anatomical_structure chemistry Case-Control Studies DNA Viral Cancer cell Cancer research RNA Viral Female barr virus Epstein business DNA Follow-Up Studies Research Article |
| Zdroj: | Asian Pacific Journal of Cancer Prevention : APJCP |
| ISSN: | 2476-762X |
| Popis: | Introduction Central nervous system tumors are a diverse group of tumors that account for 2% of all adult cancers and 17% of childhood malignancies. Several internal and external risk factors are involved in the development of this cancer such as viral infections. The aim of this study was to the determination of the EBV infection frequency and the expression level of miR-122 and miR-BART in CNS tumors samples. Methods One hundred and thirty-eight fresh tissue sample (106 case and 32 control) was collected from CNS specimens. The presence of Epstein-Barr virus (EBV) DNA was examined by PCR assay and the expression level of miR-122 and miR-BART were evaluated by using real-time PCR assay in CNS tissue samples. Results EBV DNA was detected in 17% (18 of 106) of tumors tissue samples and 6.4% (2 of 32) of control samples. according to results, there was a significant relationship between the presence of EBV-DNA with CNS tumors. Additionally, the expression level of miR-122 was significantly downregulated in the EBV-positive sample compared to that of the EBV-negative sample. Also, the level of EBV-BART1-3p expression was significantly higher in EBV-positive tumors samples than EBV-positive normal samples. Conclusion The results of this study suggest that the EBV could change the condition of cancer cells by altering the expression of miR-122 and EBV-BART1-3p and maybe contribute to the development of cancer cells. However, the role of viral infections in CNS cancer requires further studies. . |
| Databáze: | OpenAIRE |
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