Association of Early Palliative Care Use With Survival and Place of Death Among Patients With Advanced Lung Cancer Receiving Care in the Veterans Health Administration
| Autor: | Jodi Lapidus, Linda Ganzini, Donald R. Sullivan, Erik K. Fromme, Christopher G. Slatore, Sara E. Golden, Benjamin Chan, Lissi Hansen, Miguel Marino, Kelly C. Vranas, Patricia A. Carney |
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| Rok vydání: | 2019 |
| Předmět: |
Complementary Therapies
Male Cancer Research medicine.medical_specialty Palliative care Lung Neoplasms Veterans Health Time-to-Treatment 03 medical and health sciences 0302 clinical medicine Quality of life (healthcare) Acute care Internal medicine Health care Medicine Humans 030212 general & internal medicine Lung cancer Propensity Score Veterans Affairs Aged Neoplasm Staging Retrospective Studies business.industry Hazard ratio Palliative Care Cancer Middle Aged medicine.disease Survival Analysis Oncology 030220 oncology & carcinogenesis Veterans Health Services Female business |
| Zdroj: | JAMA oncology. 5(12) |
| ISSN: | 2374-2445 |
| Popis: | Importance Palliative care is a patient-centered approach associated with improvements in quality of life; however, results regarding its association with a survival benefit have been mixed, which may be a factor in its underuse. Objective To assess whether early palliative care is associated with a survival benefit among patients with advanced lung cancer. Design, Setting, and Participants This retrospective population-based cohort study was conducted among patients with lung cancer who were diagnosed with cancer between January 1, 2007, and December 31, 2013, with follow-up until January 23, 2017. Participants comprised 23 154 patients with advanced lung cancer (stage IIIB and stage IV) who received care in the Veterans Affairs health care system. Data were analyzed from February 15, 2019, to April 28, 2019. Exposure Palliative care defined as a specialist-delivered palliative care encounter received after lung cancer diagnosis. Main Outcomes and Measures The primary outcome was survival. The association between palliative care and place of death was also examined. Propensity score and time-varying covariate methods were used to calculate Cox proportional hazards and to perform regression modeling. Results Of the 23 154 patients enrolled in the study, 57% received palliative care. The mean (SD) age of participants was 68 (9.5) years, and 98% of participants were men. An examination of the timing of palliative care receipt relative to cancer diagnosis found that palliative care received 0 to 30 days after diagnosis was associated with decreases in survival (adjusted hazard ratio [aHR], 2.13; 95% CI, 1.97-2.30), palliative care received 31 to 365 days after diagnosis was associated with increases in survival (aHR, 0.47; 95% CI, 0.45-0.49), and palliative care received more than 365 days after diagnosis was associated with no difference in survival (aHR, 1.00; 95% CI, 0.94-1.07) compared with nonreceipt of palliative care. Receipt of palliative care was also associated with a reduced risk of death in an acute care setting (adjusted odds ratio, 0.57; 95% CI, 0.52-0.64) compared with nonreceipt of palliative care. Conclusions and Relevance The results suggest that palliative care was associated with a survival benefit among patients with advanced lung cancer. Palliative care should be considered a complementary approach to disease-modifying therapy in patients with advanced lung cancer. |
| Databáze: | OpenAIRE |
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