Functional Network Changes in Hippocampal CA1 after Status Epilepticus Predict Spatial Memory Deficits in Rats
| Autor: | Gregory R. Richard, Anna L. Tyler, J. M. Mahoney, Gregory L. Holmes, Pierre-Pascal Lenck-Santini, Rod C. Scott |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Male
Nerve net Entropy Models Neurological Statistics as Topic Status epilepticus Hippocampal formation Lithium Muscarinic Agonists Article Statistics Nonparametric Functional networks Rats Sprague-Dawley Status Epilepticus Predictive Value of Tests medicine Image Processing Computer-Assisted Animals Maze Learning CA1 Region Hippocampal Probability Neurons Memory Disorders General Neuroscience Pilocarpine Cognition Spatial cognition Electrodes Implanted Rats Disease Models Animal medicine.anatomical_structure nervous system Space Perception Pyramidal cell medicine.symptom Nerve Net Psychology Neuroscience medicine.drug |
| Popis: | Status epilepticus (SE) is a common neurological emergency, which has been associated with subsequent cognitive impairments. Neuronal death in hippocampal CA1 is thought to be an important mechanism of these impairments. However, it is also possible that functional interactions between surviving neurons are important. In this study we recordedin vivosingle-unit activity in the CA1 hippocampal region of rats while they performed a spatial memory task. From these data we constructed functional networks describing pyramidal cell interactions. To build the networks, we used maximum entropy algorithms previously applied only toin vitrodata. We show that several months following SE pyramidal neurons display excessive neuronal synchrony and less neuronal reactivation during rest compared with those in healthy controls. Both effects predict rat performance in a spatial memory task. These results provide a physiological mechanism for SE-induced cognitive impairment and highlight the importance of the systems-level perspective in investigating spatial cognition. |
| Databáze: | OpenAIRE |
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