Use of high flip angle in T1-prepared FAST sequences for myocardial perfusion quantification
| Autor: | Pascal Chatelain, Alberto Righetti, Marko K. Ivancevic, Dominique Didier, Larry Kasuboski, François Lazeyras, Jean-Paul Vallée |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Gadolinium DTPA Male medicine.medical_specialty Magnetic Resonance Spectroscopy Image quality Contrast Media Image processing Sensitivity and Specificity Statistics Nonparametric Flip angle Reference Values Transfer constant medicine Humans Radiology Nuclear Medicine and imaging In patient Aged Probability Analysis of Variance Phantoms Imaging business.industry Dynamic range Ultrasound Heart Signal Processing Computer-Assisted General Medicine Middle Aged Female Radiology business Nuclear medicine Perfusion Biomedical engineering |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1432-1084 0938-7994 |
| DOI: | 10.1007/s00330-002-1542-8 |
| Popis: | This study reports on the first use of high flip angle and radio-frequency (RF) spoiling in T1-prepared fast acquisition in steady state (FAST) sequence for myocardial perfusion in patients. T1 dynamic range was measured in vitro with a FAST, an RF FAST and a snapshot fast low-angle shot (FLASH) sequences with a 90 degrees flip angle. Myocardial perfusion was then measured twice in 6 patients during the same MR session. The RF FAST and FLASH, but not the FAST sequence, demonstrated an extended T1 dynamic range; however, the FLASH images were degraded by artifacts not present on the RF FAST images. The myocardial perfusion indices K1 (first-order transfer constant from the blood to the myocardium for the Gd-DTPA) and Vd (distribution volume of Gd-DTPA in myocardium) did not differ significantly between the two injections. K1 was 0.48+/-0.12 ml/min g(-1) and Vd was 12.5+/-2.9%. With an extended T1 dynamic range and the sensitivity required for myocardial perfusion quantification, the RF FAST sequence with a 90 degrees flip angle outperformed the snapshot FLASH sequence in terms of image quality and the FAST sequence in terms of contrast dynamic range. |
| Databáze: | OpenAIRE |
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