Helicobacter pylori infection is identified as a cardiovascular risk factor in Central Africans

Autor: Itoua Ngaporo Assori, Jacqueline Nkondi Nsenga, Dieudonné Ngoma Vangu, Etienne Mokondjimobe, Bertrand Ellenga-Mbolla, Simon Mbungu Fuele, Benjamin Longo-Mbenza, Jean Rosaire Ibara, Thierry Raoul Gombet
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Blood Glucose
Male
Helicobacter pylori infection
Time Factors
carotid plaque
Endocrinology
Diabetes and Metabolism
Carotid Intima-Media Thickness
Body Mass Index
Pathogenesis
cardiovascular disease
Risk Factors
Odds Ratio
Medicine
Pharmacology (medical)
Prospective Studies
Original Research
biology
Incidence
Incidence (epidemiology)
Hematology
General Medicine
stroke
Antibodies
Bacterial
Lipids
myocardial infarction
Cardiovascular Diseases
Democratic Republic of the Congo
Female
Waist Circumference
Cardiology and Cardiovascular Medicine
Risk assessment
Black People
Risk Assessment
Helicobacter Infections
Sex Factors
Humans
cardiovascular diseases
Risk factor
Chi-Square Distribution
Helicobacter pylori
business.industry
Hemodynamics
Public Health
Environmental and Occupational Health
Case-control study
Fibrinogen
Odds ratio
bacterial infections and mycoses
biology.organism_classification
Uric Acid
Vascular Health and Risk Management
Cross-Sectional Studies
Logistic Models
Case-Control Studies
Multivariate Analysis
Immunology
business
Biomarkers
Africans
Follow-Up Studies
Zdroj: Vascular Health and Risk Management
ISSN: 1178-2048
Popis: Benjamin Longo-Mbenza,1 Jacqueline Nkondi Nsenga,2 Etienne Mokondjimobe,3 Thierry Gombet,3 Itoua Ngaporo Assori,3 Jean Rosaire Ibara,3 Bertrand Ellenga-Mbolla,3 DieudonnéNgoma Vangu,4 Simon Mbungu Fuele41Faculty of Health Sciences, Walter Sisulu University, Mthatha, South Africa; 2Division of Gastroenterology, University of Kinshasa, Kinshasa, Democratic Republic of the Congo; 3Faculty of Health Sciences, University of Marien Ngouabi, Brazzaville, Democratic Republic of the Congo; 4Biostatistics Unit, Lomo Medical Center, Limete, Kinshasa, Democratic Republic of the CongoBackground: Helicobacter pylori is now incriminated in the pathogenesis of atherosclerosis.Objective: To examine the importance of H. pylori infection as a cardiovascular disease (CVD) risk factor.Methods: Two hundred five patients (128 with H. pylori infection [HP-seropositive] and 77 without) had a baseline assessment for other potential CVD risk factors and were followed prospectively for 10 years (1999–2008). They were assessed on a monthly basis for the outcomes of carotid plaque, angina pectoris, myocardial infarction, and stroke. In the HP-seropositive group, male sex and quartile 4 for IgG anti-H. pylori antibodies (anti-HP Ab) were correlated with traditional CVD risk factors, stroke, myocardial infarction, and angina pectoris.Results: At the baseline assessment, the levels of carotid intima-media thickness, blood fibrinogen, total cholesterol, fasting plasma glucose, and uric acid were higher in H. pylori-infected patients than in the uninfected group. Serum HDL-cholesterol was significantly lower in the HP-seropositive group. Men had higher levels of IgG anti-HP Ab, waist circumference, blood pressure, uric acid, and total cholesterol than women. Within the HP-seropositive group, individuals in quartile 4 for IgG anti-HP Ab had higher rates of elevated fibrinogen, diabetes mellitus, low high-density lipoprotein cholesterol, arterial hypertension, and high total cholesterol than those in quartile 1. After adjusting for traditional CVD risk factors, H. pylori infection was the only independent predictor of incident carotid plaque (multivariate odds ratio [OR] = 2.3, 95% confidence interval [CI]: 1.2–7.2; P < 0.0001) and incident acute stroke (multivariate OR = 3.6, 95% CI: 1.4–8.2; P < 0.0001). Within the HP-seropositive group and after adjusting for traditional CVD risk factors, male sex was the only independent predictor of incident angina pectoris (multivariate OR = 3.5, 95% CI: 1.6–16; P < 0.0001), incident acute stroke (multivariate OR = 3.2, 95% CI: 1.4–28; P < 0.0001), and acute myocardial infarction (multivariate OR = 7.2, 95% CI: 3.1–18; P < 0.0001).Conclusion: Our study provides evidence for an association among known CVD risk factors, carotid plaque, stroke, and H. pylori infection. Among infected individuals, there is a significant association among severity of HP-seropositivity, male sex, and CVD. The eradication of H. pylori infection may therefore reduce the emerging burden of CVD in Africa.Keywords: Helicobacter pylori, stroke, myocardial infarction, cardiovascular disease, carotid plaque, Africans
Databáze: OpenAIRE
Externí odkaz: