Most Patients With Gastroesophageal Reflux Disease Who Failed Proton Pump Inhibitor Therapy Also Have Functional Esophageal Disorders
| Autor: | Nina George, Ronnie Fass, Jason Abdallah, Stephen J. Ganocy, Takahisa Yamasaki |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Esophageal pH Monitoring SF-36 medicine.drug_class Proton-pump inhibitor Esophageal Disorder Gastroenterology 03 medical and health sciences 0302 clinical medicine Esophagus Quality of life Internal medicine medicine Electric Impedance Humans Endoscopy Digestive System Prospective Studies Treatment Failure Aged Hepatology business.industry Reflux Heartburn Proton Pump Inhibitors Middle Aged medicine.disease Prognosis digestive system diseases medicine.anatomical_structure 030220 oncology & carcinogenesis GERD Gastroesophageal Reflux Quality of Life 030211 gastroenterology & hepatology Female medicine.symptom business Follow-Up Studies |
| Zdroj: | Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 17(6) |
| ISSN: | 1542-7714 |
| Popis: | Background & Aims As many as 45% of patients with gastroesophageal reflux disease (GERD) still have symptoms after receiving once-daily proton pump inhibitor (PPI) therapy. We aimed to compare reflux characteristics and patterns between responders and non-responders to once-daily PPI therapy using combined impedance-pH monitoring. Methods Patients who reported heartburn and/or regurgitation at least twice per week for 3 months while receiving standard-dose PPI therapy were assigned to the PPI failure group (n = 16). Patients who reported a complete resolution of symptoms on once-daily PPIs for at least 4 weeks were assigned to the PPI success group (n = 13). We collected demographic data and subjects completed the short-form 36 and the GERD health-related quality of life questionnaires. Patients then underwent upper endoscopy and combined esophageal impedance-pH monitoring while on PPI therapy. Results Four patients in the PPI success group (31%) and 4 patients in the PPI failure group (25%) had abnormal results from the pH test (P = 1.00). Most of the patients in the PPI failure group (75%) were found to have either functional heartburn or reflux hypersensitivity with GERD. Impedance and pH parameters did not differ significantly between the PPI failure and success group. Conclusions We found no difference in reflux characteristics between patients with GERD who had successful vs failed once-daily PPI therapy. Most patients in the PPI failure group (75%) had functional esophageal disorders. |
| Databáze: | OpenAIRE |
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