Activity of ceftaroline against Enterococcus faecium PBP5
| Autor: | Oliver Verlaine, Xavier Henry, Ana Maria Amoroso, Jacques Coyette, Jean-Marie Frère, Bernard Joris |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Pharmacology
medicine.drug_class Cephalosporin Ceftobiprole Mutant Enterococcus faecium Human pathogen Biology biochemical phenomena metabolism and nutrition biology.organism_classification Benzylpenicillin beta-Lactam Resistance Microbiology Anti-Bacterial Agents Cephalosporins Bacterial protein Infectious Diseases Amp resistance Bacterial Proteins Mechanisms of Resistance medicine Pharmacology (medical) Ampicillin Resistance medicine.drug |
| Zdroj: | Antimicrobial agents and chemotherapy. 57(12) |
| ISSN: | 1098-6596 |
| Popis: | The opportunistic human pathogen Enterococcus faecium overproduces the low-affinity PBP5. In clinical strains, mutations in PBP5 further reduce its acylation rate by β-lactams. Previous studies have reported that ceftaroline had poor inhibitory activity against β-lactam-resistant E. faecium strains. In this study, we show that ceftaroline exhibits killing activity against our laboratory-derived ampicillin-resistant E. faecium mutant that overproduces a wild-type PBP5 and that ceftaroline inactivates PBP5 much faster than benzylpenicillin and faster than ceftobiprole. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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