Predictive Factors for Lymph Node Metastasis in Clinical Stage I Part-Solid Lung Adenocarcinoma
| Autor: | Wan Jin Hwang, Woohyun Jung, Kwhanmien Kim, Jae Hyun Jeon, So Young Lee, Mincheol Chae, Yoohwa Hwang, Sukki Cho, Sanghoon Jheon, Jin Haeng Chung |
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| Rok vydání: | 2019 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult Male medicine.medical_specialty Lung Neoplasms Standardized uptake value Adenocarcinoma of Lung 030204 cardiovascular system & hematology Metastasis 03 medical and health sciences Young Adult 0302 clinical medicine Predictive Value of Tests Risk Factors medicine Humans Lymph node Aged Neoplasm Staging Retrospective Studies Aged 80 and over Lung business.industry Retrospective cohort study Middle Aged medicine.disease Primary tumor medicine.anatomical_structure 030228 respiratory system Predictive value of tests Lymphatic Metastasis Positron-Emission Tomography Adenocarcinoma Surgery Female Radiology Lymph Nodes Cardiology and Cardiovascular Medicine business Tomography X-Ray Computed |
| Zdroj: | The Annals of thoracic surgery. 111(2) |
| ISSN: | 1552-6259 |
| Popis: | Background Accurate clinical staging of tumors with a small solid portion is essential for developing an appropriate treatment plan. This study evaluated predictive factors for lymph node (LN) metastasis in patients with clinical stage I part-solid lung adenocarcinoma. Methods Medical records of patients with clinical stage I part-solid adenocarcinoma who underwent anatomic pulmonary resection with systematic node evaluation between January 2009 and June 2018 were retrospectively reviewed. To identify predictive factors for LN metastasis, univariate and multivariable logistic regression analyses were performed. Results Among the 593 patients in this study, the overall prevalence of LN metastasis was 3.7% (n = 22), which included 3.0% (n = 18) of patients with N1 LN metastasis and 1.5% (n = 9) of patients with N2 LN metastasis. Combined N1 and N2 nodal involvement was observed in 5 patients. Nodal metastasis was not observed in tumors with a solid portion sized 1.1 cm or smaller. The nodal metastasis rates in cT1b, cT1c, and cT2a tumors were 5.5% (13 of 237), 7.1% (6 of 84), and 13.6% (3 of 22), respectively. According to the multivariable analysis, predictive factors included the size of the solid portion (P = .015) and the high maximum standardized uptake value (SUVmax) of the primary tumor (P = .044). Conclusions Large solid portion and high SUVmax of the primary tumor were predictive factors of LN metastasis in patients with clinical stage I part-solid lung adenocarcinoma. Systematic LN evaluation should be performed, especially in those who have a large solid portion and high SUVmax of the primary tumor. |
| Databáze: | OpenAIRE |
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