Blood Groups Distribution and Gene Diversity of the ABO and Rh (D) Loci in the Mexican Population
| Autor: | Adrian Canizalez-Roman, Alma M. Gaudrón Llanos, Nidia León-Sicairos, Secundino Muro-Amador, Jesús Javier Martínez-García, Jorge Velazquez-Roman, Cinthia K. Cruz-Zamudio, Héctor Flores-Villaseñor, José A. Castro-Sánchez, Francisco J. Andrade-Muñoz, Tania G. Ortíz-Espinoza, Mario A. López-Martínez, Abraham Campos-Romero, Jonathan Alcántar-Fernández |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male Adolescent Article Subject Population lcsh:Medicine Biology Genetic analysis General Biochemistry Genetics and Molecular Biology ABO Blood-Group System 03 medical and health sciences Young Adult Gene Frequency ABO blood group system Humans Allele education Child Mexico Phylogeny Aged Genetics Aged 80 and over education.field_of_study Rh-Hr Blood-Group System General Immunology and Microbiology lcsh:R Infant Newborn Infant General Medicine Middle Aged Agglutination (biology) 030104 developmental biology Cross-Sectional Studies Genetics Population Child Preschool Genetic structure biology.protein Female Antibody Rh blood group system Research Article |
| Zdroj: | BioMed Research International, Vol 2018 (2018) BioMed Research International |
| ISSN: | 2314-6133 |
| DOI: | 10.1155/2018/1925619 |
| Popis: | Objective. To determine the frequency and distribution of ABO and Rh (D) antigens and, additionally, investigate gene diversity and the structure of Mexican populations.Materials and Methods. Blood groups were tested in 271,164 subjects from 2014 to 2016. The ABO blood group was determined by agglutination using the antibodies anti-A, Anti-B, and Anti-D for the Rh factor, respectively.Results. The overall distribution of ABO and Rh (D) groups in the population studied was as follows: O: 61.82%; A: 27.44%; B: 8.93%; and AB: 1.81%. For the Rh group, 95.58% of people were Rh (D), and 4.42% were Rh (d). Different distributions of blood groups across regions were found; additionally, genetic analysis revealed that theIOandIDallele showed an increasing trend from the north to the center, while theIAandIdallele tended to increase from the center to the north. Also, we found more gene diversity in bothlociin the north compared with the center, suggesting population structure in Mexico.Conclusion. This work could help health institutions to identify where they can obtain blood products necessary for medical interventions. Moreover, this piece of information contributes to the knowledge of the genetic structure of the Mexican populations which could have significant implications in different fields of biomedicine. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |