Temporal analysis of individual ethanol consumption in socially housed mice and the effects of oxytocin
| Autor: | Andrey E. Ryabinin, Meridith T. Robins, Maya Caruso, Hannah D. Fulenwider |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
HM2
Male Time Factors Alcohol Drinking Physiology Alcohol Alcohol use disorder Oxytocin Choice Behavior 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine Sex Factors Sex differences medicine Animals Circadian rhythm Original Investigation Pharmacology RFID Ethanol Behavior Animal Dose-Response Relationship Drug business.industry Socially housed medicine.disease Oxytocin receptor Ethanol preference 030227 psychiatry Mice Inbred C57BL Alcoholism Radiofrequency identification chemistry Female Two-bottle choice Ethanol intake Dark phase business Drink size 030217 neurology & neurosurgery Injections Intraperitoneal medicine.drug |
| Zdroj: | Psychopharmacology |
| ISSN: | 1432-2072 0033-3158 |
| Popis: | Rationale The majority of preclinical studies assessing treatments for alcohol use disorder use singly housed animals. Because social factors affect ethanol intake, studies investigating such treatments in group-housed animals are needed. Objectives We investigated the effects of repeated oxytocin treatment on ethanol intake in socially housed male and female C57BL/6J mice. Methods We used the novel “Herdsman” system implementing radiotracking technology to measure individual ethanol intake in group-housed animals. Mice were housed in same-sex groups of 4 per cage and exposed to 3 and 6% ethanol solutions. After baseline drinking was established, half of the animals in each cage received repeated intraperitoneal injections of 3 mg/kg oxytocin. Results During baseline, females consumed more ethanol than males partly due to greater number of ethanol drinks taken by females. We also observed a gradual development of two peaks of ethanol consumption during the dark phase of the circadian cycle. The effects of oxytocin treatment were short-acting and varied across treatment days. Oxytocin significantly decreased ethanol intake on three out the four treatment days. On the fourth treatment day, oxytocin decreased ethanol intake and water intake. Conclusion The greater intake of ethanol in female mice is associated with the number of drinks taken. Oxytocin treatments not only cause an acute decrease in ethanol consumption, but can also change in efficacy over time. While the oxytocin system remains a promising therapeutic target for alcoholism, studies investigating longer periods of repeated oxytocin treatment and those using additional oxytocin receptor agonists are warranted. Supplementary Information The online version contains supplementary material available at 10.1007/s00213-020-05741-3. |
| Databáze: | OpenAIRE |
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