Histopathological Changes of Placenta in Meconium Stained Liquor and Its Relevance in Fetal Distress: A Case Control Study
| Autor: | Dyuti Ganguly, Sabuj Ghana Mukhopadhyay, Goutam Bandyopadhyay, Tanima Roy Mondal |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Meconium Placenta Fetal Distress 0302 clinical medicine Pregnancy Risk Factors Fetal distress Medicine Birth Weight reproductive and urinary physiology 030219 obstetrics & reproductive medicine Obstetrics Gestational age food and beverages Hydrogen-Ion Concentration Fetal Blood female genital diseases and pregnancy complications Meconium Aspiration Syndrome medicine.anatomical_structure embryonic structures Fetal Mortality Gestation Apgar score Female lcsh:RB1-214 Adult medicine.medical_specialty congenital hereditary and neonatal diseases and abnormalities Histopathology Gestational Age Pathology and Forensic Medicine 03 medical and health sciences Young Adult lcsh:Pathology Humans business.industry Cesarean Section Infant Newborn medicine.disease Amniotic Fluid Meconium stained liquor Pregnancy Complications 030104 developmental biology Case-Control Studies Apgar Score Emergencies Morbidity business |
| Zdroj: | Türk Patoloji Dergisi, Vol 35, Iss 2, Pp 107-118 (2019) |
| ISSN: | 1309-5730 |
| Popis: | Objective Meconium passage during labour is a quite common finding. Studies describing correlation between meconium stained liquor, fetal distress and specific placental pathology are sparse. This case control study had been designed to ascertain these lacunae of knowledge. Material and method Placentae from 41 cases of otherwise uncomplicated antenatal and intranatal pregnancies with meconium stained liquor at 37 completed weeks of gestation were studied, both grossly and microscopically, comparing them with controls of 41 cases of clear liquor. Apgar score of all newborns at 1 minute and 5 minutes were recorded and correlated with histopathological findings. Results Both cases and controls were found to be age matched. Meconium stained liquor was associated with more caesarian section than the clear ones. Significant correlation was found with meconium stained liquor and low Apgar scores. Histopathology of placenta revealed many statistically significant associations between specific placental histopathology in meconium stained liquor and depressed Apgar score. Evidence of placental vasculopathy rather than meconium induced placental damage came out as the potential culprit in causing a low Apgar score in this case control study. Conclusion Placental vascular changes have a role in meconium staining of liquor. If timely interventions are taken, the chance of development of fetal distress is low. |
| Databáze: | OpenAIRE |
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