Solid-State Amorphization of Linaprazan by Mechanical Milling and Evidence of Polymorphism
| Autor: | Florence Danede, Lars-Erik Briggner, Jean-François willart, Anke Marx, Morgan Durand, Marc Descamps |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Materials science
Calorimetry Differential Scanning Drug Compounding Pharmaceutical Science Proton Pump Inhibitors Calorimetry Heterocyclic Compounds 2-Ring Phase Transition Amorphous solid law.invention Crystallography Differential scanning calorimetry X-Ray Diffraction Polymorphism (materials science) Chemical engineering law Thermodynamics Particle Size Crystallization Glass transition Ball mill Powder Diffraction Powder diffraction |
| Zdroj: | Journal of Pharmaceutical Sciences. 102:2214-2220 |
| ISSN: | 0022-3549 |
| DOI: | 10.1002/jps.23573 |
| Popis: | In this paper, we study the thermodynamic and structural changes of crystalline linaprazan (a proton pump inhibitor) upon high-energy ball milling at room temperature. The investigations have been performed by differential scanning calorimetry and powder X-ray diffraction. The results indicate that this drug undergoes a direct crystal-to-glass transformation upon milling. Moreover, upon heating, the amorphous material obtained by milling is shown to recrystallize toward two different polymorphs that appear to form a monotropic set. © 2013 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 102:2214–2220, 2013 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text