Acetophenone Monomers from Acronychia trifoliolata
| Autor: | Chihiro Morita, David J. Newman, Katsunori Miyake, Kyoko Nakagawa-Goto, Airi Suzuki, Barry R. O'Keefe, Susan L. Morris-Natschke, Masuo Goto, Kuo Hsiung Lee |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Acronychia trifoliolata
Stereochemistry Pharmaceutical Science Bioinformatics 01 natural sciences Article Analytical Chemistry chemistry.chemical_compound Drug Discovery Humans Nuclear Magnetic Resonance Biomolecular Rutaceae Pharmacology Molecular Structure 010405 organic chemistry Extramural Organic Chemistry Acetophenones Antineoplastic Agents Phytogenic National Cancer Institute (U.S.) United States 0104 chemical sciences 010404 medicinal & biomolecular chemistry Monomer Complementary and alternative medicine chemistry Indonesia Plant Bark Molecular Medicine Drug Screening Assays Antitumor Human cancer Acetophenone |
| Zdroj: | Journal of Natural Products. 79:2883-2889 |
| ISSN: | 1520-6025 0163-3864 |
| Popis: | Seven new [acronyculatins I-O (1-7)] and four known acetophenone monomers were isolated from a CH 3 OH/CH 2 Cl 2 (1:1) extract (N089419) of Acronychia trifoliolata provided by the U.S. National Cancer Institute (NCI, Frederick, MD, USA). Their structures were characterized by using various NMR and HRMS techniques. Among the known compounds, the structure of acronyculatin B (8) was revised. Some of the isolated compounds were evaluated for antiproliferative activity against human cancer cell lines. While most of the tested compounds were not cytotoxic, acronyculatins I (1) and J (2) showed moderate antiproliferative activity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|