Effects of a 12-week aerobic exercise on markers of hypertension in men
| Autor: | Khadije Ebrahimi, Pouran Karimi, Mohammad Hossein Sadeghi Zali, Amir Mohammad Daneshian Moghaddam, Mohammad Sadaghian, Behrouz Baghaiee, Saeed Dabagh Nikoo Kheslat |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Exercise group 030204 cardiovascular system & hematology medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Diseases of the circulatory (Cardiovascular) system Aerobic exercise Exercise Adiponectin business.industry Lifestyle Oxidative Stress 030104 developmental biology Endocrinology Blood pressure RC666-701 Hypertension Original Article Cardiology and Cardiovascular Medicine business Training program Oxidative stress |
| Zdroj: | Journal of Cardiovascular and Thoracic Research Journal of Cardiovascular and Thoracic Research, Vol 10, Iss 3, Pp 162-168 (2018) |
| ISSN: | 2008-6830 2008-5117 |
| DOI: | 10.15171/jcvtr.2018.26 |
| Popis: | Introduction: This study was aimed at determining the effects of a 12-week aerobic exercise program on markers of hypertension in men. Methods: The study was of a semi-experimental design featuring repeated measurements. A total of 40 men (age range=37.9 ± 2.68) with primary hypertension were divided into two groups, namely, the exercise group (n=20) and the control group (n=20) (systolic blood pressure [SBP]: 140.531 ± 0.23, diastolic blood pressure [DBP]: 90.71 ± 0.05). The exercise group participated in a 12-week aerobic exercise program (55% to 70% of HRmax). Blood samples were taken from both groups at the baseline and at the 4th, 8th, and 12th weeks of the training program for the assessment of adiponectin, paraoxonase-1 (PON-1), and hydrogen peroxide (H2 O2 ) levels as the markers for investigation. A linear mixed model was also used to evaluate the association among the markers. Results: In the exercise group, exercise reduced the SBP and DBP at week 12 (P=0.031 and 0.023, respectively), and adiponectin increased at weeks 8 and 12 (P=0.014 and 0.001, respectively). The plasma PON-1 level showed a significant increase in all the three stages of measurement (P=0.007, 0.004, and 0.002 at weeks 4, 8, and 12, respectively), whereas the H2 O2 levels showed a significant decrease at weeks 8 and 12 (P=0.013 and 0.011, respectively). The control group exhibited significantly decreased PON-1 (P=0.003) and adiponectin (P=0.025) levels but significantly increased SBP at week 12 (P=0.032). Conclusion: The exercise-induced reduction of oxidative stress exerts a considerable effect on the reduction of blood pressure in hypertensive patients. According to our results increase in oxidative stress has the great impact on the of blood pressure. |
| Databáze: | OpenAIRE |
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