Experience with topiramate monotherapy in elderly patients with recent-onset epilepsy
| Autor: | Andreas Schreiner, Renzo Guerrini, Jože Grošelj, J. van Oene, Susanne Schwalen, Marjolein Lahaye |
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| Rok vydání: | 2005 |
| Předmět: |
Male
Topiramate medicine.medical_specialty medicine.medical_treatment Population Antiepileptic drug Fructose Central nervous system disease Epilepsy Internal medicine medicine Humans Prospective Studies Age of Onset education Adverse effect Aged Aged 80 and over education.field_of_study business.industry Body Weight General Medicine medicine.disease Treatment Outcome Anticonvulsant Neurology Tolerability Anesthesia Anticonvulsants Female Neurology (clinical) business medicine.drug |
| Zdroj: | Acta Neurologica Scandinavica. 112:144-150 |
| ISSN: | 1600-0404 0001-6314 |
| DOI: | 10.1111/j.1600-0404.2005.00469.x |
| Popis: | Objectives – To evaluate the effect of topiramate in elderly patients with onset of epilepsy after the age of 60, treatment-naive or non-responding to an initial antiepileptic drug. Methods – Analysis of patients with epilepsy diagnosed in the preceding 5 years, aged ≥65 years (n = 43), enrolled in a larger open-label trial (n = 692). After titration to topiramate 100 mg/day over 4 weeks, the dose was adjusted according to individual response (maximum 400 mg/day). Patients were followed up for at least 7 months. Results – After 7 months, 79% of patients remained in the study. Seizure frequency decreased significantly vs baseline (P |
| Databáze: | OpenAIRE |
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