Glucocorticoid-Associated Maternal Hyperglycemia: A Randomized Trial of Insulin Prophylaxis
| Autor: | Mary Ellen Burke Sosa, Joseph W. Hogan, Marshall W. Carpenter, Jami Star |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
Fetal acidosis business.industry Insulin medicine.medical_treatment Glucose Measurement Obstetrics and Gynecology Maternal hyperglycemia law.invention Endocrinology Postprandial Randomized controlled trial law Internal medicine Pediatrics Perinatology and Child Health medicine Betamethasone business Glucocorticoid medicine.drug |
| Zdroj: | Journal of Maternal-Fetal and Neonatal Medicine. 9:273-277 |
| ISSN: | 1476-4954 1476-7058 |
| DOI: | 10.3109/14767050009053445 |
| Popis: | Objectives: To study the degree and timing of maternal hyperglycemia following betamethasone therapy in nondiabetic patients and establish a prophylactic dose of insulin.Methods: Forty-five patients receiving betamethasone 12 mg i.m. at 7 AM on two consecutive days were randomized to no insulin (n = 20), low-dose insulin (n = 18), and high-dose insulin (n = 7) protocols. Each treatment group received s.c. insulin at 7 AM on the 2 days of betamethasone therapy (20 units NPH/10 units regular, and 40 units NPH/20 units regular, respectively). Capillary plasma glucose measurements were obtained at fasting and 2 h after meals for 3 days. A multivariate normal regression model was used to estimate and compare mean glucose levels.Results: Eighty-five percent of patients who did not receive insulin exhibited hyperglycemia at levels previously associated with fetal acidosis. Significant differences in mean postprandial plasma glucose levels were found between the no-treatment and insulin groups on days 1 and 2. No... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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