Adiponectin agonist treatment in diabetic pregnant rats
| Autor: | Marino B. Arnao, Lidia E. Martínez-Gascón, María Sánchez-Campillo, María Dolores Albaladejo-Otón, Francisca Rodriguez, Antonio Gázquez, Pedro Saura-Garre, Elvira Larqué |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty endocrine system diseases Offspring Endocrinology Diabetes and Metabolism Intrauterine growth restriction Diabetes Mellitus Experimental Random Allocation Endocrinology Piperidines Pregnancy Internal medicine Diabetes mellitus medicine Animals Birth Weight glucose Adiposity Adiponectin diabetes adiponectin business.industry Research nutritional and metabolic diseases medicine.disease female genital diseases and pregnancy complications Rats Gestational diabetes DHA Diabetes Gestational Oxidative Stress Docosahexaenoic acid Prenatal Exposure Delayed Effects Gestation Female business |
| Zdroj: | The Journal of Endocrinology |
| ISSN: | 1479-6805 0022-0795 |
| Popis: | Gestational diabetes mellitus (GDM) reduces maternal adiponectin and docosahexaenoic acid (DHA) materno-fetal transfer, which may have negative consequences for the offspring. Our aim was to evaluate the effects of the administration of a novel adiponectin agonist (AdipoRon) to GDM rats on the long-term consequences in glycaemia and fatty acids (FA) profile in the offspring. Pregnant rats were randomized to three groups: GDM rats (GDM, n = 8), GDM rats treated with AdipoRon (GDM + ADI, n = 9), and control rats (n = 10). Diabetes was induced with streptozotocin (50 mg/kg) on day 12 of gestation. GDM+ADI received 50 mg/kg/day AdipoRon from day 14 until delivery. Glycaemia and FA profile were determined in mothers and adult offspring (12 weeks old). AdipoRon tended to reduce fasting glucose in diabetic mothers. Diabetic rats presented the foetus with intrauterine growth restriction and higher adiposity, which tried to be counteracted by AdipoRon. In the adult offspring, both GDM + ADI and control animals showed better glucose recovery after oral glucose overload with respect to GDM. DHA in offspring plasma was significantly reduced in both GDM and GDM + ADI compared to controls (P = 0.043). Nevertheless, n-6/n-3 polyunsaturated FA (PUFA) ratio improved in plasma of GDM + ADI adult offspring (GDM: 14.83 ± 0.85a%; GDM + ADI: 11.49 ± 0.58b%; control: 10.03 ± 1.22b%, P = 0.034). Inflammatory markers and oxidative stress were reduced in the adult offspring of AdipoRon-treated mothers. In conclusion, AdipoRon administration to pregnant diabetic rats improved glycaemia in the mothers and long-term glucose tolerance in the offspring. In addition, it tended to reduce excessive foetal fat accumulation and improved n-6/n-3 PUFA ratio significantly in offspring at the adult state. |
| Databáze: | OpenAIRE |
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