Effects of metformin in adolescents with polycystic ovary syndrome undertaking lifestyle therapy: a pilot randomized double-blind study

Autor:	Peter A. Lee, Gwinnett Ladson, Anthony E. Archibong, Richard S. Legro, Allen R. Kunselman, Nancy I. Williams, PonJola Coney, William C. Dodson, Stephanie D. Sweet, Laurence M. Demers
Rok vydání:	2011
Předmět:	medicine.medical_specialty Randomization Time Factors endocrine system diseases Adolescent Pilot Projects Risk Assessment Article law.invention Randomized controlled trial Quality of life Double-Blind Method law Risk Factors Internal medicine Medicine Humans Testosterone Lifestyle Therapy Caloric Restriction business.industry digestive oral and skin physiology Hyperandrogenism nutritional and metabolic diseases Obstetrics and Gynecology medicine.disease Polycystic ovary Combined Modality Therapy Metformin United States Surgery Exercise Therapy Clinical trial Treatment Outcome Reproductive Medicine Quality of Life Regression Analysis Female business Risk Reduction Behavior Biomarkers medicine.drug Polycystic Ovary Syndrome
Zdroj:	Fertility and sterility. 95(8)
ISSN:	1556-5653
Popis:	Our small study does not support the addition of metformin to the lifestyle of adolescents. Although there are favorable trends toward hyperandrogenism with metformin, these must be balanced against the increased rate of gastrointestinal side effects. However, other treatments were associated with an improved quality of life. (Fertil Steril® 2011;95:2595–8.©2011 by American Society for Reproductive Medicine.)
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15e4414f836212b239b823dc9ef5c248 https://pubmed.ncbi.nlm.nih.gov/21704212 Zobrazit plný text záznamu