Structural and functional analogies and differences between histidine decarboxylase and aromatic l-amino acid decarboxylase molecular networks: Biomedical implications
| Autor: | Almudena Pino-Angeles, María Isabel Jiménez Morales, Rocío Rodríguez-López, Francisca Sánchez-Jiménez, José Luis Urdiales |
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| Rok vydání: | 2016 |
| Předmět: |
Models
Molecular 0301 basic medicine Serotonin Dopamine Cellular differentiation Histidine Decarboxylase Biology 03 medical and health sciences chemistry.chemical_compound Rare Diseases medicine Animals Humans Pharmacology chemistry.chemical_classification Aromatic L-amino acid decarboxylase Cell growth Histidine decarboxylase 030104 developmental biology Enzyme chemistry Biochemistry Aromatic-L-Amino-Acid Decarboxylases Histamine Function (biology) medicine.drug |
| Zdroj: | Pharmacological Research. 114:90-102 |
| ISSN: | 1043-6618 |
| Popis: | Human histidine decarboxylase (HDC) and dopa decarboxilase (DDC) are highly homologous enzymes responsible for the synthesis of biogenic amines (BA) like histamine, and serotonin and dopamine, respectively. The enzymes share many structural and functional analogies, while their product metabolisms also follow similar patterns that are confluent in some metabolic steps. They are involved in common physiological functions, such as neurotransmission, gastrointestinal track function, immunity, cell growth and cell differentiation. As a consequence, metabolic elements of both BA subfamilies are also co-participants in a long list of human diseases. This review summarizes the analogies and differences in their origin (HDC and DDC) as well as their common pathophysiological scenarios. The major gaps of information are also underlined, as they delay the possibility of holistic approaches that would help personalized medicine and pharmacological initiatives for prevalent and rare diseases. |
| Databáze: | OpenAIRE |
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