A Newly Identified Member of the Tumor Necrosis Factor Receptor Superfamily with a Wide Tissue Distribution and Involvement in Lymphocyte Activation
| Autor: | B S, Kwon, K B, Tan, J, Ni, K O, Oh, Z H, Lee, K K, Kim, Y J, Kim, S, Wang, R, Gentz, G L, Yu, J, Harrop, S D, Lyn, C, Silverman, T G, Porter, A, Truneh, P R, Young |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Male Signal peptide Herpesvirus entry mediator T cell Molecular Sequence Data Biology Lymphocyte Activation Vascular endothelial growth inhibitor Biochemistry Receptors Tumor Necrosis Factor Cell Line medicine Humans Tissue Distribution Amino Acid Sequence Northern blot Cloning Molecular B-cell activating factor Molecular Biology Chromosome Mapping Cell Biology Fusion protein Molecular biology medicine.anatomical_structure Chromosomes Human Pair 1 Receptors Virus Lymphotoxin beta receptor Receptors Tumor Necrosis Factor Member 14 |
| Zdroj: | Journal of Biological Chemistry. 272:14272-14276 |
| ISSN: | 0021-9258 |
| Popis: | The tumor necrosis factor receptor (TNFR) superfamily consists of approximately 10 characterized members of human proteins. We have identified a new member of the TNFR superfamily, TR2, from a search of an expressed sequence tag data base. cDNA cloning and Northern blot hybridization demonstrated multiple mRNA species, of which a 1.7-kilobase form was most abundant. However, TR2 is encoded by a single gene which, maps to chromosome 1p36.22-36.3, in the same region as several other members of the TNFR superfamily. The most abundant TR2 open reading frame encodes a 283-amino acid single transmembrane protein with a 36-residue signal sequence, two perfect and two imperfect TNFR-like cysteine-rich domains, and a short cytoplasmic tail with some similarity to 4-1BB and CD40. TR2 mRNA is expressed in multiple human tissues and cell lines and shows a constitutive and relatively high expression in peripheral blood T cells, B cells, and monocytes. A TR2-Fc fusion protein inhibited a mixed lymphocyte reaction-mediated proliferation suggesting that the receptor and/or its ligand play a role in T cell stimulation. |
| Databáze: | OpenAIRE |
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