Depression one year after hemorrhagic stroke is associated with late worsening of outcomes
| Autor: | Chitra Venkatsubramanian, Ryan W Snider, Sara Stern-Nezer, Marion S. Buckwalter, Christine A.C. Wijman, Irina Eyngorn, Michael Mlynash |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Physical Therapy Sports Therapy and Rehabilitation Severity of Illness Index 03 medical and health sciences 0302 clinical medicine Hematoma Modified Rankin Scale Rating scale Internal medicine Severity of illness Dash medicine Humans cardiovascular diseases 030212 general & internal medicine Stroke Depression (differential diagnoses) Aged Depression business.industry Modified rankin score Rehabilitation Middle Aged medicine.disease Disease Progression Physical therapy Female Neurology (clinical) business Intracranial Hemorrhages 030217 neurology & neurosurgery |
| Zdroj: | NeuroRehabilitation. 41:179-187 |
| ISSN: | 1878-6448 1053-8135 |
| DOI: | 10.3233/nre-171470 |
| Popis: | Background Poststroke depression is the most common psychiatric sequelae of stroke, and it's independently associated with increased morbidity and mortality. Few studies have examined depression after intracranial hemorrhage (ICH). Objective To investigate the relationship between depression, ICH and outcomes. Methods A substudy of the prospective Diagnostic Accuracy of MRI in Spontaneous Intracerebral Hemorrhage (DASH) study, we included 89 subjects assessed for depression 1 year after hemorrhage. A Hamilton Depression Rating Scale score >10 defined depression. Univariate, multivariable, and trend analyses evaluated relationships between depression, clinical, radiographic, and inflammatory factors and modified Rankin score (mRS) at 90 days and one year. Results Prevalence of depression at one year was 15%. Depression was not associated with hematoma volumes, presence of IVH or admission NIHSS, nor with demographic factors. Despite this, depressed patients had worse 1-year outcomes (p = 0.004) and were less likely to improve between 3 and 12 months, and more likely to worsen (p = 0.042). Conclusion This is the first study to investigate depression one year after ICH. Post-ICH depression was common and associated with late worsening of disability unrelated to initial hemorrhage severity. Further research is needed to understand whether depression is caused by worsened disability, or whether the converse is true. |
| Databáze: | OpenAIRE |
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