Hereditary Cancer Syndromes—A Primer on Diagnosis and Management, Part 2: Gastrointestinal Cancer Syndromes
| Autor: | Noemi Baffy, N. Jewel Samadder, Douglas L. Riegert-Johnson, Karthik V. Giridhar, Fergus J. Couch |
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| Rok vydání: | 2019 |
| Předmět: |
Oncology
medicine.medical_specialty Colorectal cancer business.industry MUTYH-Associated Polyposis Peutz-Jeghers Syndrome Peutz–Jeghers syndrome General Medicine medicine.disease Colorectal Neoplasms Hereditary Nonpolyposis Lynch syndrome Familial adenomatous polyposis Adenomatous Polyposis Coli Attenuated familial adenomatous polyposis Neoplastic Syndromes Hereditary Hamartomatous polyposis Internal medicine medicine Humans Juvenile polyposis syndrome Genetic Testing business Gastrointestinal Neoplasms |
| Zdroj: | Mayo Clinic Proceedings. 94:1099-1116 |
| ISSN: | 0025-6196 |
| DOI: | 10.1016/j.mayocp.2019.01.042 |
| Popis: | Hereditary causes due to mutations and defects in certain genes account for roughly 5% to 10% of all colorectal cancers. These inherited syndromes have been associated with a 60% to 100% lifetime risk for development of colorectal cancer, depending on the genetic syndrome, and many also carry an increased risk for multiple extracolonic malignancies. In this second part of a review series on hereditary cancer syndromes, the focus will be to provide guidance on the features and management of the most commonly encountered hereditary colorectal cancers and polyposis conditions including Lynch syndrome, familial adenomatous polyposis, MUTYH-associated polyposis, and hamartomatous polyposis. |
| Databáze: | OpenAIRE |
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