The response of human tumour blood flow to a fractionated course of thermoradiotherapy
| Autor: | L Komarnicky, Frank M. Waterman, Dennis B. Leeper |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Male
Hyperthermia Tumour blood flow Cancer Research Physiology Breast Neoplasms Initial heat Physiology (medical) medicine Humans Melanoma Aged Aged 80 and over Chemistry business.industry Radiation dose Dose fractionation Hyperthermia Induced Blood flow Hydrogen-Ion Concentration Middle Aged Steady state temperature medicine.disease Combined Modality Therapy Female Dose Fractionation Radiation Steady state (chemistry) Nuclear medicine business |
| Zdroj: | International Journal of Hyperthermia. 14:421-434 |
| ISSN: | 1464-5157 0265-6736 |
| DOI: | 10.3109/02656739809018245 |
| Popis: | The response of human tumour blood flow to a fractionated course of thermoradiotherapy was documented in four superficial but bulky tumours (three adenocarcinomas, one melanoma). Blood flow was measured 15, 30, 45, and 60 min after the onset of heating. These measurements were made at the same intra-tumour point during each heat fraction by use of a modified thermal clearance technique in which a correction was made for the heat dissipated by thermal conduction. This point was at least 2 cm beneath the surface in the central portion of the tumour. Extracellular pH was measured within 1 cm of this point prior to the first heat fraction and 2-3 weeks later. Hyperthermia was administered for 60 min, twice a week for 4 weeks by use of a 16-channel 915 MHz microwave applicator. Each patient also received a radiation dose of 40 Gy fractionated at 2 Gy/fx, five times a week (adenocarcinomas) or 4 Gy/fx, twice a week (melanoma). Blood flow remained relatively constant during heating after steady state conditions were attained. However, an overall decrease in tumour blood flow was observed in each patient over the course of thermoradiotherapy. In each case, a relatively small decrease in blood flow occurred between most heat fractions which resulted in an overall decrease which ranged from 50-100%. However, there was a tendency for blood flow to increase following the initial heat fraction at points where the steady state temperature was approximately 41 degrees C or less. Extracellular pH increased in two of three patients and decreased in the other. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|