Discovery of a potential biomarker for immunotherapy of melanoma: PLAC1 as an emerging target

Autor:	Roya Ghods, Jafar Mahmoudian, Ahmad-Reza Mahmoudi, Azadeh Rakhshan, Mohammad-Reza Shokri, Shaghayegh Rahdan, Mohammad-Reza Bolouri, Shima Dorafshan, Amir-Hassan Zarnani, Zahra Madjd, Mehdi Shekarabi
Rok vydání:	2020
Předmět:	0301 basic medicine Oncology Male medicine.medical_specialty Immunoconjugates Skin Neoplasms medicine.medical_treatment Immunology Disease Pregnancy Proteins Toxicology Irinotecan Targeted immunotherapy 03 medical and health sciences 0302 clinical medicine Antineoplastic Agents Immunological Placenta Internal medicine Cell Line Tumor medicine Biomarkers Tumor Immunology and Allergy Humans Molecular Targeted Therapy Melanoma Pharmacology business.industry Incidence (epidemiology) Cancer General Medicine Immunotherapy Middle Aged medicine.disease 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Potential biomarkers Female Topoisomerase I Inhibitors business
Zdroj:	Immunopharmacology and immunotoxicology. 42(6)
ISSN:	1532-2513
Popis:	Melanoma has increased in incidence worldwide prompting investigators to search for new biomarkers for targeted immunotherapy of this disease. Placenta specific 1 (PLAC1) is a new member of cancer-testis antigens with widespread expression in many types of cancer. Here, we aimed to study for the first time the expression pattern of PLAC1 in skin cancer samples including cutaneous melanoma, basal cell carcinoma (BCC), squamous cell carcinoma (SCC) in comparison to normal skin and nevus tissues and potential therapeutic effect of anti-PLAC1 antibody in melanoma cancer cell linesPolyclonal and monoclonal antibodies were applied for immunohistochemical profiling of PLAC1 expression using tissue microarray. The cytotoxic action of anti-PLAC1 antibody alone or as an antibody drug conjugate (with anti-neoplastic agent SN38) was investigated in melanoma cell lines.We observed that 100% (39 of 39) of melanoma tissues highly expressed PLAC1 with both cytoplasmic and surface expression pattern. Investigation of PLAC1 expression in BCC (Our findings re-inforce the concept of re-expression of embryonic/placental tissue antigens in cancer and highlight the possibility of melanoma targeted therapy by employing anti-PLAC1 antibodies. The data presented here should lead to the future research on targeted immunotherapy of patients with melanoma.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d8b3d2d040949c3b7eaafb601db335 https://pubmed.ncbi.nlm.nih.gov/33106058 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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