The Role of Gas Exchange Variables in Cardiopulmonary Exercise Testing for Risk Stratification and Management of Heart Failure with Reduced Ejection Fraction
| Autor: | Jonathan R. Wagner, Romualdo Belardinelli, Marshall Riley, Piergiuseppe Agostoni, Daniel Dumitrescu, Tim Takken, Jonathan Myers, Alfred Hager, Ross Arena, Rainer Rauramaa, Arno Schmidt-Trucksäss |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Prognostic variable Management of heart failure MEDLINE 030204 cardiovascular system & hematology Risk Assessment 03 medical and health sciences Oxygen Consumption 0302 clinical medicine Ventricular Dysfunction medicine Humans 030212 general & internal medicine Intensive care medicine Heart Failure Ejection fraction Pulmonary Gas Exchange business.industry Stroke Volume Stroke volume medicine.disease Heart failure Risk stratification Exercise Test business Risk assessment Cardiology and Cardiovascular Medicine |
| Zdroj: | American Heart Journal, 202, 116. Mosby Inc. |
| ISSN: | 0002-8703 |
| Popis: | Heart failure with reduced ejection fraction (HFrEF) is common in the developed world and results in significant morbidity and mortality. Accurate risk assessment methods and prognostic variables are therefore needed to guide clinical decision making for medical therapy and surgical interventions with the ultimate goal of decreasing risk and improving health outcomes. The purpose of this review is to examine the role of cardiopulmonary exercise testing (CPET) and its most commonly used ventilatory gas exchange variables for the purpose of risk stratification and management of HFrEF. We evaluated five widely studied gas exchange variables from CPET in HFrEF patients based on nine previously used systematic criteria for biomarkers. This paper provides clinicians with a comprehensive and critical overview, class recommendations and evidence levels. Although some CPET variables met more criteria than others, evidence supporting the clinical assessment of variables beyond peak V̇O2 is well-established. A multi-variable approach also including the V̇E-V̇CO2 slope and EOV is therefore recommended. |
| Databáze: | OpenAIRE |
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