Interaction of glucagon and epinephrine in the control of hepatic glucose production in the conscious dog
| Autor: | Ying Yang, Paul J. Flakoll, E. Patrick Donahue, Doss W. Neal, Chang An Chu, Alan D. Cherrington, Makoto Nishizawa, Ben Farmer, Stephanie M. Gustavson |
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| Rok vydání: | 2003 |
| Předmět: |
Blood Glucose
Glycerol Male medicine.medical_specialty Hepatic glucose Glycogenolysis Consciousness Epinephrine Physiology Endocrinology Diabetes and Metabolism Blood Pressure Fatty Acids Nonesterified Glucagon Increased Gluconeogenesis Dogs Heart Rate Physiology (medical) Internal medicine Increased Glycogenolysis medicine Animals Lactic Acid Alanine Chemistry Gluconeogenesis Ketones Glucose Endocrinology Liver Female Glycogen medicine.drug |
| Zdroj: | American Journal of Physiology-Endocrinology and Metabolism. 284:E695-E707 |
| ISSN: | 1522-1555 0193-1849 |
| DOI: | 10.1152/ajpendo.00308.2002 |
| Popis: | Epinephrine increases net hepatic glucose output (NHGO) mainly via increased gluconeogenesis, whereas glucagon increases NHGO mainly via increased glycogenolysis. The aim of the present study was to determine how the two hormones interact in controlling glucose production. In 18-h-fasted conscious dogs, a pancreatic clamp initially fixed insulin and glucagon at basal levels, following which one of four protocols was instituted. In G + E, glucagon (1.5 ng · kg−1· min−1; portally) and epinephrine (50 ng · kg−1· min−1; peripherally) were increased; in G, glucagon was increased alone; in E, epinephrine was increased alone; and in C, neither was increased. In G, E, and C, glucose was infused to match the hyperglycemia seen in G + E (∼250 mg/dl). The areas under the curve for the increase in NHGO, after the change in C was subtracted, were as follows: G = 661 ± 185, E = 424 ± 158, G + E = 1,178 ± 57 mg/kg. Therefore, the overall effects of the two hormones on NHGO were additive. Additionally, glucagon exerted its full glycogenolytic effect, whereas epinephrine exerted its full gluconeogenic effect, such that both processes increased significantly during concurrent hormone administration. |
| Databáze: | OpenAIRE |
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