Marathon Race Affects Neutrophil Surface Molecules: Role of Inflammatory Mediators

Autor: Kim Guimarães Caçula, Maysa Braga Barros Silva, Ana Paula Rennó Sierra, Rodrigo Cardoso de Oliveira, Marino Benetti, Diego Ribeiro de Souza, Olivia Santos Gondim, Nabil Ghorayeb, Heloisa Helena de Oliveira, Renata Gorjão, Maria Fernanda Cury-Boaventura, Adriana Cristina Levada-Pires, Maria Elizabeth Pereira Passos, Fabio Takeo Sato, Maria Augusta P. D. Kiss, Tânia Cristina Pithon-Curi, Cesar Miguel Momesso, Vinicius Coneglian Santos
Jazyk: angličtina
Rok vydání: 2016
Předmět:
0301 basic medicine
Male
Neutrophils
Physiology
lcsh:Medicine
Apoptosis
DNA fragmentation
Pathology and Laboratory Medicine
Biochemistry
Neutrophil Activation
Running
Pathogenesis
chemistry.chemical_compound
White Blood Cells
Leukocyte Count
0302 clinical medicine
Animal Cells
Immune Physiology
Medicine and Health Sciences
lcsh:Science
Immune Response
Innate Immune System
Multidisciplinary
biology
Cell Death
Interleukin
Hematology
Fas receptor
Body Fluids
Nucleic acids
Blood
Hematocrit
Cell Processes
Antigens
Surface
Cytokines
Tumor necrosis factor alpha
medicine.symptom
Cellular Types
Anatomy
Inflammation Mediators
Research Article
Adult
Cell Survival
Immune Cells
education
Immunology
Inflammation
03 medical and health sciences
Signs and Symptoms
Diagnostic Medicine
Lactate dehydrogenase
medicine
Genetics
Humans
Leukocyte Rolling
Hemoglobin
Blood Cells
business.industry
lcsh:R
Biology and Life Sciences
Proteins
030229 sport sciences
Cell Biology
DNA
Molecular Development
Blood Counts
030104 developmental biology
chemistry
Immune System
biology.protein
Creatine kinase
lcsh:Q
business
human activities
Developmental Biology
Zdroj: PLoS ONE
PLoS ONE, Vol 11, Iss 12, p e0166687 (2016)
ISSN: 1932-6203
Popis: The fatigue induced by marathon races was observed in terms of inflammatory and immunological outcomes. Neutrophil survival and activation are essential for inflammation resolution and contributes directly to the pathogenesis of many infectious and inflammatory conditions. The aim of this study was to investigate the effect of marathon races on surface molecules related to neutrophil adhesion and extrinsic apoptosis pathway and its association with inflammatory markers. We evaluated 23 trained male runners at the Sao Paulo International Marathon 2013. The following components were measured: hematological and inflammatory mediators, muscle damage markers, and neutrophil function. The marathon race induced an increased leukocyte and neutrophil counts; creatine kinase (CK), lactate dehydrogenase (LDH), CK-MB, interleukin (IL)-6, IL-10, and IL-8 levels. C-reactive protein (CRP), IL-12, and tumor necrosis factor (TNF)-α plasma concentrations were significantly higher 24 h and 72 h after the marathon race. Hemoglobin and hematocrit levels decreased 72 h after the marathon race. We also observed an increased intercellular adhesion molecule-1 (ICAM-1) expression and decreasedTNF receptor-1 (TNFR1) expression immediately after and 24 h after the marathon race. We observed an increased DNA fragmentation and L-selectin and Fas receptor expressions in the recovery period, indicating a possible slow rolling phase and delayed neutrophil activation and apoptosis. Marathon racing affects neutrophils adhesion and survival in the course of inflammation, supporting the “open-window” post-exercise hypothesis.
Databáze: OpenAIRE
Externí odkaz: