Notch polymorphisms associated with sensitivity of noise induced hearing loss among Chinese textile factory workers

Autor: Enmin Ding, Haiyan Song, Hengdong Zhang, Wei Gong, Huanxi Shen, Baoli Zhu, Jing Liu
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
0301 basic medicine
Multifactor Dimensionality Reduction
Gene Expression
010501 environmental sciences
01 natural sciences
Surveys and Questionnaires
Haplotype
Receptor
Notch1
Genetics (clinical)
medicine.diagnostic_test
Middle Aged
Occupational Diseases
Textile Industry
Cohort
Audiometry
Pure-Tone
Female
Noise-induced hearing loss
Research Article
Adult
lcsh:Internal medicine
lcsh:QH426-470
Single-nucleotide polymorphism
Polymorphism
Single Nucleotide
Work related
03 medical and health sciences
Asian People
Environmental health
Genetics
medicine
otorhinolaryngologic diseases
Humans
Genetic Predisposition to Disease
lcsh:RC31-1245
Genotyping
0105 earth and related environmental sciences
Notch1
Multifactor dimensionality reduction
business.industry
medicine.disease
Single nucleotide polymorphism
lcsh:Genetics
030104 developmental biology
Haplotypes
Hearing Loss
Noise-Induced
Case-Control Studies
Audiometry
business
NIHL
Zdroj: BMC Medical Genetics, Vol 19, Iss 1, Pp 1-9 (2018)
BMC Medical Genetics
ISSN: 1471-2350
Popis: Background Noise induced hearing loss (NIHL) is a polygenic disease involving both genetic and environmental factors, and is one of the most important occupational health hazards worldwide. To date, the influence of Notch1 variants on the risk to develop NIHL has not been illuminated. This study was conducted to explore the effects of Notch1 polymorphisms on individual susceptibility to NIHL. Methods A total of 2689 industrial workers from one textile factory in east China were recruited to participate in the current study. Venous blood was collected, basic clinical data was obtained by questionnaires and pure-tone audiometry (PTA) tests were conducted by specialist physicians. Next we performed genotyping of three selected SNPs (rs3124594, rs3124599 and rs3124603) in the Notch1 gene in 535 NIHL patients and 535 controls. Subsequently, the main effects of the genotypes and their interactions were evaluated. Results Our results revealed that individuals with a GG of rs3124594, TT of rs3124603 (OR = 4.70 and 1.59 respectively) and the haplotype AAC (rs3124594-rs3124599-rs3124603) (OR = 14.95) were associated with an increased risk of NIHL in our study cohort. Stratified analysis showed that an increased NIHL risk was found in individuals exposed to work related noise for ≤16 years that also had the rs3124594 GG or rs3124603 CT/TT genotype with an OR of 4.20 and 1.73 respectively. Multifactor dimensionality reduction analysis indicated that rs3124594, rs3124599 and rs3124603 interacted with each other and were related to an increased risk to develop NIHL (OR = 3.60). Conclusions The genetic polymorphisms rs3124594 and rs3124603 within the Notch1 gene are associated with an increased risk of NIHL in a Chinese population and could potentially be used as biomarkers for NIHL in noise exposed workers.
Databáze: OpenAIRE
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