Prevalence of gastro-esophageal reflux disease in patients with difficult to control asthma and effect of proton pump inhibitor therapy on asthma symptoms, reflux symptoms, pulmonary function and requirement for asthma medications
| Autor: | Pravin Rathi, J M Joshi, M. Murugesh, Shobna J Bhatia, A Kate, Vaibhav S Banait, V. Sandur |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Adolescent medicine.drug_class Proton-pump inhibitor lcsh:Medicine Peak Expiratory Flow Rate Gastroesophageal reflux disease Gastroenterology Pulmonary function testing pulmonary function test Internal medicine Forced Expiratory Volume medicine Prevalence Humans Prospective Studies proton pump inhibitor therapy Prospective cohort study Lung Omeprazole Asthma Aged medicine.diagnostic_test business.industry lcsh:R Reflux Proton Pump Inhibitors General Medicine Forced Expiratory Flow Rates Middle Aged medicine.disease Respiratory Function Tests Treatment Outcome GERD Physical therapy Gastroesophageal Reflux Female bronchial asthma Esophageal pH monitoring business medicine.drug |
| Zdroj: | Journal of Postgraduate Medicine, Vol 60, Iss 3, Pp 282-286 (2014) |
| ISSN: | 0972-2823 0022-3859 |
| Popis: | Background: The hypothesis that GER can trigger or exacerbate asthma is supported by several clinical trials that have shown amelioration in asthma symptoms and/or an improvement in pulmonary function after antireflux therapy. Aims: To investigate the prevalence of GER in patients with difficult to control asthma and to determine the effect of omeprazole on asthma symptoms, reflux symptoms, pulmonary function and on the requirement of asthma medications. Materials and Methods: Patients with difficult to control asthma were recruited into the study. All patients underwent esophageal manometry and 24 hour esophageal pH monitoring. Pulmonary function tests were done before and after treatment. The severity of asthma and reflux was assessed by a 1 week pulmonary symptom score(PSS) and reflux symptom score(RSS) respectively before and after treatment. Those who had an abnormal pH study (pH 5% of the time) underwent anti-GER treatment with lifestyle changes, and a proton pump inhibitor (omeprazole 40 mg, bid) for 3 months. Asthma medications were added or deleted based on severity of asthma. Results: Out of 250 asthmatic patients screened, forty patients fulfilled the inclusion criteria. Twenty eight of 40 patients(70%) were diagnosed to have GERD. Of the patients 28 with GER, 8 patients(28.5%) had no reflux symptoms. On 24 hr pH metry, the percentage time pH |
| Databáze: | OpenAIRE |
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