Diagnosis and treatments for oropharyngeal dysphagia: effects of capsaicin evaluated by newly developed ultrasonographic method
Autor: | Noriaki Manabe, Ken Haruma, Rui Nakato, Hiroaki Kusunoki, Jiro Hata, Kozo Hanayama |
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Rok vydání: | 2020 |
Předmět: |
Agonist
medicine.medical_specialty Physiology medicine.drug_class substance P TRPV1 TRPV Cation Channels Aspiration pneumonia Doppler imaging Gastroenterology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine transient receptor potential vanilloid 1 Swallowing Internal medicine medicine Humans Invited Review business.industry musculoskeletal neural and ocular physiology Ultrasonography Doppler General Medicine medicine.disease oropharyngeal dysphagia Pathophysiology ultrasonographic tissue Doppler imaging nervous system chemistry Capsaicin lipids (amino acids peptides and proteins) 030211 gastroenterology & hepatology medicine.symptom Deglutition Disorders Gastrointestinal Motility business 030217 neurology & neurosurgery Oropharyngeal dysphagia |
Zdroj: | Journal of Smooth Muscle Research |
ISSN: | 1884-8796 0916-8737 |
Popis: | Oropharyngeal dysphagia (OD) is a common symptom in the older people, and may cause fatal complications such as aspiration pneumonia. However, there is no established treatment for OD. The relationship between the transient receptor potential vanilloid 1 (TRPV1) and substance P released by activated TRPV1 was recently demonstrated. Further, there are several reports showing that capsaicin, a specific agonist of TRPV1, can improve OD. Currently, the evaluation of swallowing is mainly performed by videofluoroscopic examination. However, there are no reports on the clinical application of ultrasonography using tissue Doppler imaging. In this review, we describe the pathophysiology and treatments for OD, introduce our novel US method to evaluate cervical esophageal motility, and then outline our clinical study examining the effects of capsaicin, a specific TRPV1 agonist, in older patients with OD. |
Databáze: | OpenAIRE |
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