Premature luteinization during controlled ovarian hyperstimulation for in vitro fertilization-embryo transfer has no impact on pregnancy outcome
| Autor: | Richard T. Scott, Jennifer Thie, Chad A. Johnson, Jane Khoury, Glen E. Hofmann |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Male medicine.medical_specialty Pregnancy Rate medicine.medical_treatment Fertilization in Vitro Controlled ovarian hyperstimulation Biology Luteal phase Chorionic Gonadotropin Intracytoplasmic sperm injection Andrology Corpus Luteum Pregnancy medicine Humans Ovarian reserve Progesterone reproductive and urinary physiology Retrospective Studies Gynecology In vitro fertilisation Ovary Obstetrics and Gynecology Embryo Transfer medicine.disease Embryo transfer Pregnancy rate Reproductive Medicine Area Under Curve Female |
| Zdroj: | Fertility and Sterility. 66:980-986 |
| ISSN: | 0015-0282 |
| DOI: | 10.1016/s0015-0282(16)58693-2 |
| Popis: | To determine if elevated serum P concentration on the day of hCG administration or P area under the curve (AUC) impacts on pregnancy rates (PRs) in IVF-ET cycles.Retrospective study.One hundred thirty-three couples underwent IVF-ET using luteal GnRH-agonist suppression followed by hyperstimulation with gonadotropins. Patient cycles were controlled for female age, ovarian reserve, male factor with intracytoplasmic sperm injection (ICSI), endometrial thickness and pattern, number of embryos, and number of high-quality embryos transferred, and cell stage at transfer. Pregnancy was defined as an ongoing pregnancy20 weeks.Patients and cycle parameters did not differ significantly based on the control parameters. Similar numbers of severe male factors treated by ICSI were in each group with similar PRs. Pregnancy rates and implantation rates did not differ based on P levelsor = 0.9,or = 1.1, andor = 1.4 ng/mL (conversion factor to SI unit, 3.18). Serum P concentrations per total eggs retrieved or per mature egg retrieved did not influence pregnancy outcome. Efficiency curves for serum P levels and P AUC did not demonstrate any differences in PR. At very high serum P (P2.0 ng/mL) samples size limits the ability of these data to rule out a negative effect.Serum P levels (and P AUC) commonly encountered during cycles of IVF-ET have no impact on pregnancy outcome. |
| Databáze: | OpenAIRE |
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