No Diabetogenic Effect of N-Nitrosomethylurea on Pregnant BALB/c Mice and Their Progeny
| Autor: | H. Zühlke, Christel Voss |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Diabetes Mellitus Experimental BALB/c Mice chemistry.chemical_compound Endocrinology Pregnancy Internal medicine Diabetes mellitus Internal Medicine medicine Animals Mice Inbred BALB C Glucose tolerance test Dose-Response Relationship Drug biology medicine.diagnostic_test business.industry Methylnitrosourea General Medicine biology.organism_classification medicine.disease Dose–response relationship chemistry Nitrosamine Toxicity Pregnancy Animal Gestation Female business |
| Zdroj: | Experimental and Clinical Endocrinology & Diabetes. 92:20-24 |
| ISSN: | 1439-3646 0947-7349 |
| Popis: | Our studies give evidence that N-nitrosomethylurea applied to BALB/c mice one day before or after mating or during pregnancy (12th day) even in small (16 or 32 mg/kg) and repeated doses (16 mg/kg on 5 consecutive days, total dose 80 mg/kg) is a more toxic than potent diabetogenic agent. Mortality rises in parent mice and their progeny with no influence on glucose tolerance test and blood glucose level over the whole investigation period (4 hours-12 weeks). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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