Recent development and applications of semipinacol rearrangement reactions

Autor:	Bao-Sheng Li, Xiao-Ming Zhang, Yong-Qiang Tu, Shao-Hua Wang, Fu-Min Zhang, Kun Zhang
Rok vydání:	2021
Předmět:	Chemistry chemistry.chemical_compound chemistry 010405 organic chemistry Enantioselective synthesis Nanotechnology Organic synthesis General Chemistry 010402 general chemistry 01 natural sciences 0104 chemical sciences Quaternary carbon Semipinacol rearrangement
Zdroj:	Chemical Science
ISSN:	2041-6539 2041-6520
Popis:	As has been well-recognized, semipinacol rearrangement functions as an exceptionally useful methodology in the synthesis of β-functionalized ketones, creation of quaternary carbon centers, and construction of challenging carbocycles. Due to their versatile utilities in organic synthesis, development of novel rearrangement reactions has been a vibrant topic that continues to shape the research field. Recent breakthroughs in novel electrophiles, tandem processes, and enantioselective catalytic transformations further enrich the toolbox of this chemistry and spur the strategic applications of this methodology in natural product synthesis. These achievements will be discussed in this minireview. The recent development of semipinacol rearrangement is reviewed, highlighting its application in β-functionalized ketone synthesis, quaternary carbon formation and total synthesis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15c7eced2469ee2691b0c0e81127e98d https://doi.org/10.1039/d1sc02386a Zobrazit plný text záznamu