Uptake of lipid core nanoparticles by fragments of tissues collected during cerebral tumor excision surgeries: hypotheses for use in drug targeting therapy

Autor: Edmundo Luís Rodrigues Pereira, Danielle Cristinne Azevedo Feio, João Pojucan Lobo Tavares, Natalia Megumi Morikawa, Debora Fernandes Deus, Carolina Graziani Vital, Elaine Rufo Tavares, Raul Cavalcante Maranhão
Rok vydání: 2022
Předmět:
Zdroj: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
ISSN: 1573-7373
Popis: Malignant cerebral tumors have poor prognosis and the blood-brain barrier is a major hindrance for most drugs to reach those tumors. Lipid nanoparticles (LDE) that bind to lipoprotein receptors may carry anticancer drugs and penetrate the cells through those receptors that are overexpressed in gliomas. The aim was to investigate the in vivo uptake of LDE by human cerebral tumors.Twelve consecutive patients (4 with glioblastomas, 1 meduloblastoma, 1 primary lymphoma, 2 with non-cerebral metastases and 4 with benign tumors) scheduled for tumor excision surgery were injected intravenously, 12 h before surgery, with LDE labeledTumor LDE uptake (range: 10-283 d.p.m./g of tissue) was not lower than that of normal tissues (range: 20-263 d.p.m./g). Malignant tumor uptake was threefold greater than benign tumor uptake (140 ± 93 vs 46 ± 18 d.p.m./g, p 0.05). Results show that LDE can concentrate in brain malignant tumors and may be used to carry drugs directed against those tumors.As LDE was previously shown to markedly decrease drug toxicity this new therapeutic strategy should be tested in future trials.
Databáze: OpenAIRE
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